Prediction of vascular invasion using a 7-point scale computed tomography grading system in adrenal tumors in dogs
| Autor: | Pascaline Pey, Swan Specchi, Federica Rossi, Alessia Diana, Ignazio Drudi, Allison L. Zwingenberger, Philipp D. Mayhew, Luciano Pisoni, Daniele Mari, Federico Massari, Boris Dalpozzo, Federico Fracassi, Stefano Nicoli |
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| Přispěvatelé: | Pascaline Pey, Swan Specchi, Federica Rossi, Alessia Diana, Ignazio Drudi, Allison L. Zwingenberger, Philipp D. Mayhew, Luciano Pisoni, Daniele Mari, Federico Massari, Boris Dalpozzo, Federico Fracassi, Stefano Nicoli |
| Rok vydání: | 2022 |
| Předmět: |
Adrenal Gland Neoplasms
canine Pheochromocytoma carcinoma thrombu Rare Diseases Dogs Retrospective Studie Dog Animals Veterinary Sciences Dog Diseases Tomography Cancer Retrospective Studies Cross-Sectional Studie screening and diagnosis General Veterinary Animal Prevention X-Ray Computed Adrenal Gland Neoplasm Detection Cross-Sectional Studies thrombus Biomedical Imaging Dog Disease Tomography X-Ray Computed CT 4.2 Evaluation of markers and technologies |
| Zdroj: | Journal of veterinary internal medicine, vol 36, iss 2 |
| ISSN: | 1939-1676 |
| Popis: | Background: Previous studies evaluating the accuracy of computed tomography (CT) in detecting caudal vena cava (CVC) invasion by adrenal tumors (AT) used a binary system and did not evaluate for other vessels. Objective: Test a 7-point scale CT grading system for accuracy in predicting vascular invasion and for repeatability among radiologists. Build a decision tree based on CT criteria to predict tumor type. Methods: Retrospective observational cross-sectional case study. Abdominal CT studies were analyzed by 3 radiologists using a 7-point CT grading scale for vascular invasion and by 1 radiologist for CT features of AT. Animals: Dogs with AT that underwent adrenalectomy and had pre- and postcontrast CT. Results: Ninety-one dogs; 45 adrenocortical carcinomas (50%), 36 pheochromocytomas (40%), 9 adrenocortical adenomas (10%) and 1 unknown tumor. Carcinoma and pheochromocytoma differed in pre- and postcontrast attenuation, contralateral adrenal size, tumor thrombus short- and long-axis, and tumor and thrombus mineralization. A decision tree was built based on these differences. Adenoma and malignant tumors differed in contour irregularity. Probability of vascular invasion was dependent on CT grading scale, and a large equivocal zone existed between 3 and 6 scores, lowering CT accuracy to detect vascular invasion. Radiologists' agreement for detecting abnormalities (evaluated by chance-corrected weighted kappa statistics) was excellent for CVC and good to moderate for other vessels. The quality of postcontrast CT study had a negative impact on radiologists' performance and agreement. Conclusions and Clinical Importance: Features of CT may help radiologists predict AT type and provide probabilistic information on vascular invasion. |
| Databáze: | OpenAIRE |
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