Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients

Autor: Pignon, Jean-Pierre, le Maître, Aurélie, Maillard, Emilie, Bourhis, Jean, Amand, C, Armand, JP, Luboinski, B, Lefebvre, JL, Syz, N, Bernier, J, Budach, V, Forastiere, AA, Stewart, AA, Vokes, EE, Adelstein, DJ, Audry, H, Bachaud, JM, Bartelink, HG, Bezwoda, WR, Buffoli, A, Bhowmik, KT, Browman, GP, Calais, G, Campbell, BH, Carugati, A, Chalkidou, S, Clark, JR, Cohen, E, Collette, L, Dal Canton, O, Dalley, D, Despondt, J, Désigné, L, Deszcz-Thomas, A, Di Blasio, B, Dobrowsky, W, Domenge, C, Eschwege, F, Evensen, JF, Fallai, C, Fischer, JJ, Forastière, AA, Fountzilas, G, Fu, KK, Gedouin, D, Guérin, S, Geara, F, Giglio, R, Gupta, NK, Haddad, E, Haffy, BG, Hasegawa, Y, Hill, C, Horiot, JC, Horiuchi, M, Houghton, J, Huguenin, P, Jan, P, Jaulerry, Ch, Jeremic, B, Jouffroy, T, Jortay, A, Kapstad, B, Kowalski, LP, Kramer, S, Krishnamurthi, KS, Kumar, S, Laramore, G, Lartigau, E, Leong, T, Lewin, F, Luboinski, M, Maipang, T, Martin, M, Mazeron, JJ, Merlano, M, Metha, S, Molinari, R, Monson, K, Morita, K, Mueller, RP, Murias, A, Mosseri, V, Numico, G, Olmi, P, O'Sullivan, B, Overgaard, Jens, Paccagnella, A, Pajak, T, Parvinen, LM, Pearlman, NW, Rao, RS, Richard, JM, Rufibach, K, Sanchiz, F, Sancho-Garnier, H, Schuller, DE, Shanta, V, Simes, RJ, Smid, L, Stewart, LA, Staar, S, Strojan, P, Stuetzer, H, Szpirglas, H, Schwaab, G, Takaku, S, Taylor, SG, Tobias, JS, Toohill, RJ, Volling, P, Weissler, MC, Wendt, T, Wernecke, KD, Widder, J, Wolf, GT
Přispěvatelé: Guided Treatment in Optimal Selected Cancer Patients (GUTS)
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Zdroj: Radiotherapy and Oncology, 92(1), 4-14. ELSEVIER IRELAND LTD
Pignon, J-P, le Maître, A, Maillard, E, Bourhis, J, Amand, C, Armand, JP, Luboinski, B, Lefebvre, JL, Syz, N, Bernier, J, Budach, V, Forastiere, AA, Stewart, AA, Vokes, EE, Adelstein, DJ, Audry, H, Bachaud, JM, Bartelink, HG, Bezwoda, WR, Buffoli, A, Bhowmik, KT, Browman, GP, Calais, G, Campbell, BH, Carugati, A, Chalkidou, S, Clark, JR, Cohen, E, Collette, L, Dal Canton, O, Dalley, D, Despondt, J, Désigné, L, Deszcz-Thomas, A, Di Blasio, B, Dobrowsky, W, Domenge, C, Eschwege, F, Evensen, JF, Fallai, C, Fischer, JJ, Forastière, AA, Fountzilas, G, Fu, KK, Gedouin, D, Guérin, S, Geara, F, Giglio, R, Gupta, NK, Haddad, E, Haffy, BG, Hasegawa, Y, Hill, C, Horiot, JC, Horiuchi, M, Houghton, J, Huguenin, P, Jan, P, Jaulerry, C, Jeremic, B, Jouffroy, T, Jortay, A, Kapstad, B, Kowalski, LP, Kramer, S, Krishnamurthi, KS, Kumar, S, Laramore, G, Lartigau, E, Lefebvre, JL, Leong, T, Lewin, F, Luboinski, B, Luboinski, M, Maipang, T, Martin, M, Mazeron, JJ, Merlano, M, Metha, S, Molinari, R, Monson, K, Morita, K, Mueller, RP, Murias, A, Mosseri, V, Numico, G, Olmi, P, O'Sullivan, B, Overgaard, J, Paccagnella, A, Pajak, T, Parvinen, LM, Pearlman, NW, Rao, RS, Richard, JM, Rufibach, K, Sanchiz, F, Sancho-Garnier, H, Schuller, DE, Shanta, V, Shanta, V, Simes, RJ, Smid, L, Stewart, LA, Staar, S, Strojan, P, Stuetzer, H, Szpirglas, H, Schwaab, G, Takaku, S, Taylor, SG, Taylor, SG, Tobias, JS, Toohill, RJ, Vokes, EE, Volling, P, Weissler, MC, Wendt, T, Wernecke, KD, Widder, J & Wolf, GT 2009, ' Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients ', Radiotherapy & Oncology, vol. 92, no. 1, pp. 4-14 . https://doi.org/10.1016/j.radonc.2009.04.014
ISSN: 0167-8140
DOI: 10.1016/j.radonc.2009.04.014
Popis: BACKGROUND: Our previous individual patient data (IPD) meta-analysis showed that chemotherapy improved survival in patients curatively treated for non-metastatic head and neck squamous cell carcinoma (HNSCC), with a higher benefit with concomitant chemotherapy. However the heterogeneity of the results limited the conclusions and prompted us to confirm the results on a more complete database by adding the randomised trials conducted between 1994 and 2000.METHODS: The updated IPD meta-analysis included trials comparing loco-regional treatment to loco-regional treatment+chemotherapy in HNSCC patients and conducted between 1965 and 2000. The log-rank-test, stratified by trial, was used to compare treatments. The hazard ratios of death were calculated.RESULTS: Twenty-four new trials, most of them of concomitant chemotherapy, were included with a total of 87 trials and 16,485 patients. The hazard ratio of death was 0.88 (pCONCLUSION: The benefit of concomitant chemotherapy was confirmed and was greater than the benefit of induction chemotherapy.
Databáze: OpenAIRE
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