Loss of retinoic acid receptor-beta expression is an early event during esophageal carcinogenesis
| Autor: | Scott M. Lippman, Wei Zhang, Reuben Lotan, Hongming Qiu, Xiao Chun Xu, Adel K. El-Naggar, Peizhong Lin |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Pathology medicine.medical_specialty Esophageal Neoplasms Receptors Retinoic Acid Retinoic acid Biology Pathology and Forensic Medicine chemistry.chemical_compound medicine Humans Esophagus Aged Esophageal disease Cell Differentiation Esophageal cancer Middle Aged medicine.disease Immunohistochemistry Up-Regulation Esophageal Tissue Gene Expression Regulation Neoplastic Retinoic acid receptor medicine.anatomical_structure Epidermoid carcinoma chemistry embryonic structures Cancer research Adenocarcinoma Female Regular Articles |
| Zdroj: | The American journal of pathology. 155(5) |
| ISSN: | 0002-9440 |
| Popis: | We recently observed that growth inhibition of esophageal cancer cells by retinoic acid (RA) was associated with both constitutive expression and RA-induced up-regulation of RA receptor beta (RAR-beta). Cell lines that did not express RAR-beta were also resistant to RA. To explore the expression of RAR-beta mRNA in vivo, we analyzed esophageal tissue specimens from 16 normal mucosae, 30 dysplastic lesions, and 157 esophageal tumors by in situ hybridization. RAR-beta was detected in 88% (14/16) of normal esophageal tissues and in 96% (96/100) of distant normal esophageal mucosa from cancer specimens. In contrast, RAR-beta was expressed in only 57% (17/30) of dysplastic lesions and in 54% (84/157) of carcinomas. Among esophageal carcinomas RAR-beta mRNA was expressed in 62% (26/42) of well-differentiated, 54% (27/50) of moderately differentiated, and only 29% (4/14) of poorly differentiated SCCs. Our data suggest that the loss of RAR-beta expression is an early event associated with esophageal carcinogenesis and the status of squamous differentiation. |
| Databáze: | OpenAIRE |
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