Green Asparagus (Asparagus officinalis) Prevented Hypertension by an Inhibitory Effect on Angiotensin-Converting Enzyme Activity in the Kidney of Spontaneously Hypertensive Rats
| Autor: | Matsuda Sanae, Aoyagi Yasuo |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Renal function Angiotensin-Converting Enzyme Inhibitors Blood Pressure Peptidyl-Dipeptidase A Kidney Excretion Rats Inbred SHR Internal medicine medicine Animals Humans Asparagus Antihypertensive Agents chemistry.chemical_classification biology food and beverages General Chemistry biology.organism_classification Rats medicine.anatomical_structure Enzyme Blood pressure Endocrinology chemistry Biochemistry Hypertension Officinalis ACE inhibitor Plant Preparations Asparagus Plant General Agricultural and Biological Sciences Azetidinecarboxylic Acid medicine.drug |
| Zdroj: | Journal of Agricultural and Food Chemistry. 61:5520-5525 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/jf3041066 |
| Popis: | Green asparagus (Asparagus officinalis) is known to be rich in functional components. In the present study, spontaneously hypertensive rats (SHR) were used to clarify whether green asparagus prevents hypertension by inhibition of angiotensin-converting enzyme (ACE) activity. Six-week-old male SHR were fed a diet with (AD group) or without (ND group) 5% asparagus for 10 weeks. Systolic blood pressure (SBP) (AD: 159 ± 4.8 mmHg, ND: 192 ± 14.7 mmHg), urinary protein excretion/creatinine excretion, and ACE activity in the kidney were significantly lower in the AD group compared with the ND group. Creatinine clearance was significantly higher in the AD group compared with the ND group. In addition, ACE inhibitory activity was observed in a boiling water extract of asparagus. The ACE inhibitor purified and isolated from asparagus was identified as 2″-hydroxynicotianamine. In conclusion, 2″-hydroxynicotianamine in asparagus may be one of the factors inhibiting ACE activity in the kidney, thus preventing hypertension and preserving renal function. |
| Databáze: | OpenAIRE |
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