Effects and mechanisms of water-soluble Semen cassiae polysaccharide on retinitis pigmentosa in rats
| Autor: | Cong Ma, Xiuhong Qin, Xiang Ma, Shi-Feng Fang, Qinggui Meng, Suiqin He, Jianmin Lu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Retina Retinal Photoreceptor Cells lcsh:TX341-641 Semen Retinal medicine.disease Polysaccharide Andrology chemistry.chemical_compound Water soluble medicine.anatomical_structure chemistry Apoptosis polysaccharide retinitis pigmentosa lcsh:Technology (General) Retinitis pigmentosa medicine lcsh:T1-995 Semen cassiae lcsh:Nutrition. Foods and food supply Food Science Biotechnology |
| Zdroj: | Food Science and Technology, Issue: ahead, Published: 15 JUL 2019 Food Science and Technology, Volume: 40, Issue: 1, Pages: 84-88, Published: 15 JUL 2019 Food Science and Technology v.40 n.1 2020 Food Science and Technology (Campinas) Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) instacron:SBCTA Food Science and Technology |
| Popis: | This study aimed to investigate the effects and mechanisms of water-soluble Semen cassiae polysaccharide (SCP) on retinitis pigmentosa (RP) in rats. One hundred rats were randomly divided into control, model, and 50, 100 and 200 mg/kg SCP groups. The 50, 100 and 200 mg/kg SCP groups were treated with 50, 100 and 200 mg/kg SCP for 5 days, respectively. On the sixth day, the model, and 50, 100 and 200 mg/kg SCP groups were treated with N-nitroso-N-methylurea (MNU). After 12 h and 5 days, the electroretinogram, retinal thickness, apoptosis of retinal photoreceptor cells, and expressions of apoptosis related protein in retina tissue were determined. Results showed that, after 12 h and on 5 days from MNU treatment, compared with model group, the a-wave and b-wave amplitude and retinal thickness in SCP groups were significantly increased, the apoptosis rate of retinal photoreceptor cells was significantly decreased, the Bcl-2 protein expression level in retinal tissue was significantly increased, and the Bax and Caspase-3 protein level were significantly decreased (all P < 0.05). In conclusion, SCP has obvious protective effects on RP in rats. The mechanism may be related to it regulation of Bcl-2, Bax and Caspase-3 protein expression in retina tissue. |
| Databáze: | OpenAIRE |
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