Isotopomics by isotope ratio monitoring by 13 C nuclear magnetic resonance spectrometry on cutting agents in heroin: A new approach for illicit drugs trafficking route elucidation
| Autor: | Fabrice Besacier, Valentin Joubert, Serge Akoka, Anne-Marie Schiphorst, Matéo Trébuchet, Anaïs Stemmelen, Virginie Silvestre, Denis Loquet, Mariana Mikic, Virginie Ladroue, Gérald S. Remaud |
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| Přispěvatelé: | Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Laboratoire de Police Scientifique de Lyon (INPS), Institut National de la Police Scientifique, Institut National de Police Scientifique (INPS), Laboratoire d'analyse isotopique et électrochimique de metabolismes (LAIEM), Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
paracetamol
illicit drug [SDV]Life Sciences [q-bio] Pharmaceutical Science Poison control Drug profiling Mass spectrometry 01 natural sciences Analytical Chemistry 03 medical and health sciences MESH: Acetaminophen / analysis Analgesics Opioid / chemistry* Caffeine / analysis Carbon Isotopes / analysis Drug Trafficking Heroin / chemistry* Illicit Drugs / chemistry* Magnetic Resonance Spectroscopy / methods Mass Spectrometry 0302 clinical medicine Environmental Chemistry [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology 030216 legal & forensic medicine Spectroscopy caffeine Chromatography Isotope Chemistry Stable isotope ratio 010401 analytical chemistry irm-13C NMR Carbon-13 NMR Nuclear magnetic resonance spectrometry 0104 chemical sciences Isotopic ratio isotopic profile |
| Zdroj: | Drug Testing and Analysis Drug Testing and Analysis, John Wiley, 2020, 12 (4), pp.449-457. ⟨10.1002/dta.2745⟩ |
| ISSN: | 1942-7603 1942-7611 |
| DOI: | 10.1002/dta.2745⟩ |
| Popis: | International audience; In the battle against the illicit drugs market, methodologies have been developed by forensic laboratories to address the determination of the origin and dismantlement of the trafficking route for various target molecules such as heroin and cocaine. These drug profiling methods are not straightforward, especially when the target molecules are synthetic and very pure, resulting in poorly informative impurity profiles, e.g. new psychoactive substances and cutting agents. A tool based on the determination of intramolecular isotopic profiles has been developed to provide origin discrimination with a new way to profile seized cutting agents and heroin samples. Whereas stable isotope analyses by mass spectrometry give the bulk isotopic composition, nuclear magnetic resonance gives direct access to the position-specific isotope content at natural abundance. This report shows how both 13 C NMR spectrometry and 13 C, 15 N MS might provide complementary and valuable information to link seized caffeine and paracetamol to their origin. Here, isotopic ratio monitoring by 13 C NMR (irm-13 C NMR) offers additional benefits over irm-MS in its capability to determine a detailed isotopic profile, leading to a better method to distinguish different caffeine and paracetamol batches. |
| Databáze: | OpenAIRE |
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