Walking, Gross Motor Development, and Brain Functional Connectivity in Infants and Toddlers
| Autor: | Mark D. Shen, Chloe M. Adams, Joseph Piven, Heather C. Hazlett, Guido Gerig, Alan C. Evans, Kelly N. Botteron, Stephen R. Dager, Lyndsey Cole, Robert W. Emerson, Robert C. McKinstry, Lonnie Zwaigenbaum, Annette Estes, Jason J. Wolff, Juhi Pandey, Robert T. Schultz, Meghan R. Swanson, Adam T. Eggebrecht, Bradley L. Schlaggar, Natasha Marrus, Alexandre A. Todorov, Jed T. Elison, Cheryl L. Klohr, Sarah Paterson, John N. Constantino, Wei Gao, John R. Pruett, Martin Styner |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Autism Spectrum Disorder Nerve net Cognitive Neuroscience Gross motor skill Walking gross motor 050105 experimental psychology 03 medical and health sciences Cellular and Molecular Neuroscience Child Development 0302 clinical medicine Physical medicine and rehabilitation Neural Pathways Humans Medicine 0501 psychology and cognitive sciences Longitudinal Studies Toddler Default mode network Resting state fMRI business.industry functional connectivity 05 social sciences Brain Infant Cognition Original Articles medicine.disease Magnetic Resonance Imaging Child development medicine.anatomical_structure Autism spectrum disorder Child Preschool network Female Nerve Net business 030217 neurology & neurosurgery |
| Zdroj: | Cerebral Cortex (New York, NY) |
| ISSN: | 1460-2199 1047-3211 |
| DOI: | 10.1093/cercor/bhx313 |
| Popis: | Infant gross motor development is vital to adaptive function and predictive of both cognitive outcomes and neurodevelopmental disorders. However, little is known about neural systems underlying the emergence of walking and general gross motor abilities. Using resting state fcMRI, we identified functional brain networks associated with walking and gross motor scores in a mixed cross-sectional and longitudinal cohort of infants at high and low risk for autism spectrum disorder, who represent a dimensionally distributed range of motor function. At age 12 months, functional connectivity of motor and default mode networks was correlated with walking, whereas dorsal attention and posterior cingulo-opercular networks were implicated at age 24 months. Analyses of general gross motor function also revealed involvement of motor and default mode networks at 12 and 24 months, with dorsal attention, cingulo-opercular, frontoparietal, and subcortical networks additionally implicated at 24 months. These findings suggest that changes in network-level brain–behavior relationships underlie the emergence and consolidation of walking and gross motor abilities in the toddler period. This initial description of network substrates of early gross motor development may inform hypotheses regarding neural systems contributing to typical and atypical motor outcomes, as well as neurodevelopmental disorders associated with motor dysfunction. |
| Databáze: | OpenAIRE |
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