Transfer of proteins into mitochondria. Precursor to the ADP/ATP carrier binds to receptor sites on isolated mitochondria
| Autor: | Craig Zwizinski, Walter Neupert, Manfred Schleyer |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Reticulocytes
Receptors Cytoplasmic and Nuclear Receptors Cell Surface Mitochondrion Biology Biochemistry Neurospora crassa Membrane Potentials Receptor Molecular Biology Membrane potential Isolated mitochondria Enzyme Precursors Cell-Free System fungi Cell Biology Intracellular Membranes Mitochondrial carrier biology.organism_classification Nucleotidyltransferases Cell biology Mitochondria Kinetics Neurospora ATP–ADP translocase Mitochondrial ADP ATP Translocases |
| Zdroj: | The Journal of biological chemistry. 258(7) |
| ISSN: | 0021-9258 |
| Popis: | The precursor form of Neurospora crassa mitochondrial ADP/ATP carrier synthesized in a cell-free protein-synthesizing system can be imported into isolated mitochondria. If the mitochondrial transmembrane potential is abolished, import does not occur but the precursor binds to the mitochondrial surface. Upon reestablishment of the membrane potential, the bound precursor is imported. This occurs without dissociation of the bound precursor from the mitochondrial surface. We conclude that the binding observed represents an interaction with receptor sites and thus is an early step in the import pathway. |
| Databáze: | OpenAIRE |
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