Large keratoacanthomas treated with intralesional interferon alfa-2a
| Autor: | Jean-Jacques Grob, Jean-Jacques Bonerandi, H. Zarour, C. Noe, M.H. Munoz, F. Suzini, M. Weiller, Marie Aleth Richard |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Keratoacanthoma medicine.medical_treatment Interferon alfa-2a Scars Alpha interferon Dermatology Injections Intralesional Interferon alpha-2 Skin Diseases Cicatrix Interferon medicine Humans Child Interferon alfa Aged Aged 80 and over business.industry Interferon-alpha virus diseases Immunotherapy Middle Aged medicine.disease Recombinant Proteins Surgery Cytokine Female medicine.symptom business medicine.drug |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0190-9622 |
| DOI: | 10.1016/0190-9622(93)70174-r |
| Popis: | Background: Spontaneous involution of giant keratoacanthomas (KAs) can leave large scars or cause mutilation. Human papillomaviruses have recently been demonstrated in KAs. Intralesional interferon alfa-2a (IFN alfa-2a) has been shown to have activity against different epithelial tumors and to have an antiviral effect. Objective: This study was conducted to determine whether it was possible to stop extension of large KAs, to accelerate healing, and to obtain good cosmetic results with intralesional IFN alfa-2a. Methods: Six large KAs were treated with intralesional IFN alfa-2a. Results: Regression was obtained in five cases in 3 to 7 weeks with excellent cosmetic results. The main side effect was pain during injection. Conclusion: Our results suggest that this treatment hastens healing and limits scarring. |
| Databáze: | OpenAIRE |
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