The incidence of acute kidney injury in children undergoing allogenic hematopoietic stem cell transplantation: A pilot study
| Autor: | Danuta Zwolińska, Krzysztof Kałwak, Monika Augustynowicz, Kinga Musiał |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Medicine (miscellaneous) Renal function Pilot Projects Hematopoietic stem cell transplantation General Biochemistry Genetics and Molecular Biology Risk Factors Internal medicine Internal Medicine medicine Retrospective analysis Humans Pharmacology (medical) Stage (cooking) Child Genetics (clinical) Retrospective Studies business.industry Incidence (epidemiology) Incidence Acute kidney injury Hematopoietic Stem Cell Transplantation Acute Kidney Injury medicine.disease Transplantation Reviews and References (medical) business Pediatric population |
| Zdroj: | Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 30(1) |
| ISSN: | 1899-5276 |
| Popis: | Background Acute kidney injury (AKI) is a common feature in adults undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). However, accurate assessment of AKI incidence in the pediatric population still seems a challenge. Objectives To evaluate the incidence of AKI according to the pRIFLE criteria in children undergoing alloHSCT, with special focus on differences between patients transplanted due to oncological and non-oncological indications. Material and methods A retrospective analysis of data, concerning 135 children undergoing alloHSCT due to oncological (89 patients) or other (46 patients) reasons, was performed. The values of estimated glomerular filtration rate (eGFR) were measured before alloHSCT, 24 h after, 1, 2, 3, 4, 8 weeks, 3 and 6 months after alloHSCT, and the AKI incidence was analyzed. Results Acute kidney injury was diagnosed in 54% of all patients. The Risk stage (R) was noticed at least once in 46% of oncological and 37% of non-oncological children. The Injury stage (I) concerned 12% of oncological and 6% of non-oncological patients undergoing alloHSCT. The incidence of AKI in both groups was comparable. The mean eGFR values in oncological children were higher than those in the non-oncological patients even before transplantation and until the 4th week after alloHSCT. The eGFR increased significantly in all patients 24 h after alloHSCT and returned to pre-transplantation records after 2-3 weeks. Then, oncological patients demonstrated a gradual decrement of eGFR. Six months after transplantation, eGFR values in oncological children were significantly lower compared to pre-transplantation records, whereas in non-oncological children, these values were comparable. Conclusions Although the type of indication for alloHSCT has no impact on the AKI incidence, children undergoing alloHSCT due to oncological reasons are at greater risk of renal impairment 6 months after transplantation than non-oncological patients. |
| Databáze: | OpenAIRE |
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