Can cryoprevention of oral mucositis be obtained at a higher temperature?

Autor: Mats Jontell, A. Mahdi, Java Walladbegi, J. Stübner, M. Bergling
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Clinical Oral Investigations
ISSN: 1436-3771
1432-6981
Popis: Objectives Ice chips (IC) have successfully been used to prevent the development of chemotherapy-induced oral mucositis (OM). Although effective, IC entails several shortcomings and may open avenues for systemic infections as the water used may be contaminated by microorganisms, which may jeopardise the medical rehabilitation of an already immunosuppressed patient. This study aimed to investigate the efficacy and tolerability profile of a novel intraoral cooling device (ICD). Subjects and methods In total, 20 healthy volunteers were enrolled in this randomised crossover study. Intraoral temperatures were registered using an IR camera, at baseline and following 30 and 60 min of cooling with the ICD, set to 8 °C or 15 °C. Following each cooling session, tolerability was assessed using a questionnaire. Results A statistically significant difference in the intraoral temperature was observed using 8 °C compared with 15 °C, following both 30 (1.87 °C, p p p Conclusion Cooling was better tolerated when the ICD was set to 15 °C compared with 8 °C, although the difference in reduction of the intraoral mucosal temperature was marginal and may not affect cryoprevention of oral mucositis. Clinical relevance The ICD has the potential to improve the care for patients with cancer at high risk of developing OM.
Databáze: OpenAIRE
Externí odkaz: