Modest maternal caffeine exposure affects developing embryonic cardiovascular function and growth
| Autor: | John C. Ralphe, Huda Elshershari, Joseph P. Tinney, Kimimasa Tobita, Bradley B. Keller, Nobuo Momoi, Li J. Liu, Paul J. Hoffmann |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Receptor Adenosine A2A Physiology Injections Subcutaneous Adenosine A2A receptor Gestational Age Abortion Biology Adenosine A1 Receptor Antagonists Cardiovascular System Crown-Rump Length Ultrasonography Prenatal Umbilical Arteries chemistry.chemical_compound Mice Pregnancy Physiology (medical) Internal medicine Caffeine medicine Animals RNA Messenger Aorta Crown-rump length Echocardiography Doppler Pulsed Fetal Growth Retardation Receptor Adenosine A1 Hemodynamics Gestational age medicine.disease Adenosine A2 Receptor Antagonists Endocrinology Carotid Arteries chemistry Fetal Weight In utero Maternal Exposure Regional Blood Flow Xanthines Embryo Loss Gestation Central Nervous System Stimulants Female Cardiology and Cardiovascular Medicine Blood Flow Velocity |
| Zdroj: | American journal of physiology. Heart and circulatory physiology. 294(5) |
| ISSN: | 0363-6135 |
| Popis: | Caffeine consumption during pregnancy is reported to increase the risk of in utero growth restriction and spontaneous abortion. In the present study, we tested the hypothesis that modest maternal caffeine exposure affects in utero developing embryonic cardiovascular (CV) function and growth without altering maternal hemodynamics. Caffeine (10 mg·kg−1·day−1 subcutaneous) was administered daily to pregnant CD-1 mice from embryonic days (EDs) 9.5 to 18.5 of a 21-day gestation. We assessed maternal and embryonic CV function at baseline and at peak maternal serum caffeine concentration using high-resolution echocardiography on EDs 9.5, 11.5, 13.5, and 18.5. Maternal caffeine exposure did not influence maternal body weight gain, maternal CV function, or embryo resorption. However, crown-rump length and body weight were reduced in maternal caffeine treated embryos by ED 18.5 ( P < 0.05). At peak maternal serum caffeine concentration, embryonic carotid artery, dorsal aorta, and umbilical artery flows transiently decreased from baseline at ED 11.5 ( P < 0.05). By ED 13.5, embryonic aortic and umbilical artery flows were insensitive to the peak maternal caffeine concentration; however, the carotid artery flow remained affected. By ED 18.5, baseline embryonic carotid artery flow increased and descending aortic flow decreased versus non-caffeine-exposed embryos. Maternal treatment with the adenosine A2A receptor inhibitor reproduced the embryonic hemodynamic effects of maternal caffeine exposure. Adenosine A2A receptor gene expression levels of ED 11.5 embryo and ED 18.5 uterus were decreased. Results suggest that modest maternal caffeine exposure has adverse effects on developing embryonic CV function and growth, possibly mediated via adenosine A2A receptor blockade. |
| Databáze: | OpenAIRE |
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