Brief early handling increases morphine dependence in adult rats
| Autor: | Vincent Vazquez, Marie-Jo Besson, C. Durand, J. Penit-Soria, Bruno Giros, Valérie Daugé |
|---|---|
| Přispěvatelé: | Neurobiologie et Psychiatrie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Neurobiologie des processus adaptatifs (NPA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Male
Narcotics medicine.drug_class Receptors Opioid mu Gene Expression Pharmacology Handling Psychological μopioid receptors Behavioral Neuroscience chemistry.chemical_compound Place preference paradigm Pregnancy Opioid receptor medicine Animals RNA Messenger In Situ Hybridization Analysis of Variance Ethanol Behavior Animal Endothelin-1 Morphine Handling Morphine dependence Central Nervous System Depressants [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences Conditioned place preference Rats Preproenkephalin mRNA Animals Newborn chemistry Oral morphine and ethanol self-administration Autoradiography Conditioning Operant Rat Female Self-administration Psychology Morphine Dependence medicine.drug |
| Zdroj: | Behavioural Brain Research Behavioural Brain Research, 2006, 170, pp.211-218. ⟨10.1016/j.bbr.2006.02.022⟩ Behavioural Brain Research, Elsevier, 2006, 170, pp.211-218. ⟨10.1016/j.bbr.2006.02.022⟩ |
| ISSN: | 0166-4328 1872-7549 |
| DOI: | 10.1016/j.bbr.2006.02.022⟩ |
| Popis: | Short early manipulations of rodent postnatal environment may trigger long-term effects on neurobiological and behavioural phenotypes in adulthood. However, little is known about such effects of handling on the vulnerability to develop drug dependence. The present study aimed to analyze the long-term effects of a brief handling (1 min) on morphine and ethanol dependence and on the preproenkephalin (PPE) mRNA and mu opioid receptor levels. Handled rats showed a significant increase in morphine (25mg/l) but not ethanol (10%) consumption and preference after 7 weeks and no difference in morphine (2 and 5mg/kg) conditioned place preference. No difference of preproenkephalin mRNA and mu opioid receptor levels was detected in the mesolimbic system between both groups. These data emphasize that human brief handling, which can lead to morphine dependence development, constitutes in itself an experimental treatment and not a control condition. |
| Databáze: | OpenAIRE |
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