Sequence of four new HLA-Cw alleles: a possible role of interallelic recombination
| Autor: | Jean-Marie Tiercy, L. Gebuhrer, Q.-G. Steiner, Christophe Grundschober, F. Javaux, M.-P. Labonne |
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| Rok vydání: | 1998 |
| Předmět: |
Silent mutation
DNA Complementary Immunology Molecular Sequence Data Blood Donors Human leukocyte antigen HLA-C Antigens Biology Biochemistry White People Exon Polymorphism (computer science) Antigens Neoplasm Sequence Homology Nucleic Acid Genetics Immunology and Allergy Humans Amino Acid Sequence Allele Peptide sequence Gene Alleles Recombination Genetic Base Sequence Sequence Homology Amino Acid General Medicine Sequence Analysis DNA Neoplasm Proteins Europe Melanoma-Specific Antigens Recombination |
| Zdroj: | Tissue antigens. 51(1) |
| ISSN: | 0001-2815 |
| Popis: | In order to extend our current understanding of HLA-C polymorphism, four new alleles have been cloned and sequenced: Cw*1801 in a donor of mixed origin, Cw*02024 in a Senegalese individual, Cw*1205 and Cw*1604 in European Caucasoid blood donors. HLA-Cw*1801, which most likely results from an interallelic recombination between Cw*0704 and 0401 alleles, was not associated with B*8101, but with either B*4403 or B18. The Cw*02024 allele differs from Cw*02022 by a silent mutation in exon 3. Both Cw*1801 and Cw*02024 appear to be rather frequent in populations of African origin but have not yet been detected in Caucasoids. HLA-Cw*1604 differs from Cw*1601 by two nucleotides at codon 156 leading to a Gln to Trp substitution. This new Cw16 subtype was subsequently identified in three additional unrelated families, all of South-European origin, and presented an unusual association with B*4402 in all cases. HLA-Cw*1205 is a composite allele with the alpha1 domain of Cw*1602 and the alpha2 domain of Cw*1203. It appears to be rare, at least in European Caucasoids. Three of these four alleles may have resulted from gene conversion-like or interallelic recombination events. |
| Databáze: | OpenAIRE |
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