THREE-DIMENSIONAL ANALYSIS OF RETINAL MICROANEURYSMS WITH ADAPTIVE OPTICS OPTICAL COHERENCE TOMOGRAPHY
| Autor: | Ursula Schmidt-Erfurth, Julia Hafner, Matthias Salas, Michael Pircher, Sonja Karst, Wolfgang Drexler, Wolf-Dieter Vogl, Christoph Scholda |
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| Rok vydání: | 2019 |
| Předmět: |
Male
genetic structures Pilot Projects Context (language use) 01 natural sciences 010309 optics 03 medical and health sciences chemistry.chemical_compound Imaging Three-Dimensional 0302 clinical medicine Optical coherence tomography 0103 physical sciences Humans Medicine Fluorescein Angiography Adaptive optics Aged Plexus Diabetic Retinopathy medicine.diagnostic_test business.industry Retinal Vessels Retinal General Medicine Middle Aged Microaneurysm Fluorescein angiography eye diseases Ophthalmology Cross-Sectional Studies chemistry 030221 ophthalmology & optometry Female sense organs Tomography business Nuclear medicine Tomography Optical Coherence Preclinical imaging |
| Zdroj: | Retina. 39:465-472 |
| ISSN: | 0275-004X |
| DOI: | 10.1097/iae.0000000000002037 |
| Popis: | Purpose To characterize retinal microaneurysms (MAs) in patients with diabetes using adaptive optics optical coherence tomography (AOOCT) and compare details found in AOOCT with those found in commercially available retinal imaging techniques. Methods Patients with diabetes and MA in the macular area were included in this pilot study. The area of interest, identified in standard fluorescein angiography, was imaged using an AO fundus camera and AOOCT. Microaneurysms were characterized in AOOCT (visibility, reflectivity, feeding/draining vessels, and intraretinal location) and compared with findings in AO fundus camera, OCT angiography, and fluorescein angiography. Results Fifty-three MAs were imaged in 15 eyes of 10 patients. Feeding and/or draining vessels from both capillary plexus could be identified in 34 MAs in AOOCT images. Of 45 MAs imaged with OCT angiography, 18 (40%) were visible in the superior plexus, 12 (27%) in the deep capillary plexus, and 15 MAs (33%) could not be identified at all. Intraluminal hyperreflectivity, commonly seen in AO fundus camera, corresponded only in 8 of 27 cases (30%) to intraluminal densities seen in AOOCT. Conclusion Adaptive optics OCT imaging revealed that MAs located in the inner nuclear layer were connected to the intermediate and/or deep capillary plexus. Intraluminal hyperreflectivity seen on AO fundus camera images originated from a strong reflection from the vessel wall and only in a third of the cases from intraluminal clots. Currently, AOOCT is the most expedient in vivo imaging method to capture morphologic details of retinal microvasculature in 3D and in the context of the surrounding retinal anatomy. |
| Databáze: | OpenAIRE |
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