Correlations between plasma strontium concentration, components of calcium and phosphate metabolism and renal function in type 2 diabetes mellitus
| Autor: | Ronald G. H. J. Maatman, Albert J. de Graaf, Gerjan Navis, Stephan J. L. Bakker, Gozewijn D. Laverman, Christina M. Gant, Yvette Sophie van den Berkhof |
|---|---|
| Přispěvatelé: | Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Value, Affordability and Sustainability (VALUE), Groningen Institute for Organ Transplantation (GIOT) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Fibroblast growth factor 23
Male inorganic chemicals medicine.medical_specialty Clinical Biochemistry 030232 urology & nephrology Renal function chemistry.chemical_element Type 2 diabetes Calcium Biochemistry Severity of Illness Index Phosphates 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine medicine Humans Diabetic Nephropathies 030212 general & internal medicine Renal Insufficiency Chronic Aged Type 2 Diabetes Mellitus General Medicine Middle Aged medicine.disease Fibroblast Growth Factors Fibroblast Growth Factor-23 Endocrinology chemistry Diabetes Mellitus Type 2 Strontium Multivariate Analysis Linear Models Female Kidney disease Calcification Glomerular Filtration Rate |
| Zdroj: | European Journal of Clinical Investigation, 48(9):e12987. Wiley |
| ISSN: | 0014-2972 |
| Popis: | BACKGROUND: Renal function decline in diabetic kidney disease is accompanied by calcium and phosphate metabolism alterations. Whereas Strontium (Sr2+ ) has many similarities with calcium, little is known about Sr2+ in this respect. We studied the association of plasma Sr2+ concentration and parameters associated with an altered calcium and phosphate metabolism in diabetic kidney disease.MATERIALS AND METHODS: Plasma Sr2+ concentration was measured in 450 patients included in the DIAbetes and LifEstyle Cohort Twente-1. Patients were classified based on chronic kidney disease (CKD) stages: stages 1-2, stage 3 and stages 4-5 (estimated glomerular filtration rate of ≥60 mL·min-1 ·1.73m-2 , 30-59 mL·min-1 ·1.73m-2 and ≤29 mL·min-1 ·1.73m-2 , respectively). The associations between log-transformed plasma Sr2+ concentration and parameters of calcium and phosphate metabolism were studied using multivariate linear regression analysis.RESULTS: Overall, median plasma Sr2+ concentration was in normal range, 269 nmol/L, but was progressively higher in patients with lower renal function, i.e. 246 nmol/L (CKD 1-2), 347 nmol/L (CKD 3) and 419 nmol/L (CKD 4-5). In multivariate analysis, independent associations were found between plasma Sr2+ concentration and both eGFR (β=-0.401, pCONCLUSIONS: We found an independent inverse association between eGFR and plasma Sr2+ concentration and an independent association between plasma Sr2+ concentration and plasma FGF23 concentration, a marker of deranged calcium and phosphate metabolism. Further research is needed to determine the mechanisms behind these associations and the impact of an elevation in plasma Sr2+ concentration on bone mineralization and calcification. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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