Еvaluate the Effectiveness of Accelerated Collagen Crosslinking in the Treatment of Corneal Endothelial Decompensation
| Autor: | S. Yu. Astakhov, Sanasar S. Papanyan, Sergey A. Novikov, Inna A. Riks |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
ultraviolet radiation medicine.medical_specialty Visual acuity genetic structures photosensitizer medicine.medical_treatment Fuchs Endothelial Dystrophy 03 medical and health sciences 0302 clinical medicine Ophthalmology Cornea medicine fuchs’ endothelial corneal dystrophy Decompensation riboflavin corneal collagen crosslinking Corneal transplantation Corneal Decompensation business.industry Corneal Diseases RE1-994 eye diseases 030104 developmental biology medicine.anatomical_structure 030221 ophthalmology & optometry Bullous keratopathy sense organs bullous keratopathy medicine.symptom business |
| Zdroj: | Oftalʹmologiâ, Vol 17, Iss 4, Pp 699-704 (2020) |
| ISSN: | 2500-0845 1816-5095 |
| DOI: | 10.18008/1816-5095-2020-4-699-704 |
| Popis: | The article discusses the effectiveness of accelerated collagen crosslinking in the treatment of patients with corneal diseases, a common basic pathogenetic link of which is endothelial corneal decompensation. This method was used to treat patients with bullous keratopathy and endothelial dystrophy of Fuchs’ cornea with a long postoperative follow-up. In connection with the controversial results of researchers, reflecting the positive dynamics of the postoperative period, the question of the expediency of accelerated collagen cross-linking in patients with this pathology as a monotherapy is discussed.The study included 25 patients (26 eyes) with mean age 69.10 ± 10.61 years (40 to 82 years). There was Fuchs corneal endothelial dystrophy in 16 patients (17 eyes), in 9 patients (10 eyes) — stage II, in 7 patients (7 eyes) — stage III. Bullous keratopathy was present in 9 patients (9 eyes). All patients underwent treatment according to the method of accelerated collagen corneal crosslinking. In patients with bullous keratopathy (9 eyes), the data on the central thickness of the cornea and the maximum corrected visual acuity did not differ from the initial data at any of the postoperative visits, and did not differ from each other (p > 0.83). On the contrary, in some patients the dystrophic process progressed in the form of the appearance of fibrotic changes in the stroma of the cornea. Corneal transplantation was recommended to all patients under observation after treatment at different periods of observation. In patients with Fuchs endothelial dystrophy, a significant difference in the maximum corrected visual acuity from the initial data was observed only 6 months after surgery.The expediency of accelerated collagen cross-linking in the treatment of patients with corneal diseases accompanied by endothelial decompensation as monotherapy is very doubtful. The study of combined surgical methods for treating this complex corneal pathology using cross-linking as an auxiliary method seems promising. |
| Databáze: | OpenAIRE |
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