A persistently low HBV DNA level is a predictor of spontaneous HBsAg clearance in patients with chronic hepatitis B
| Autor: | Şebnem Çalik, Selma Tosun, Sibel Özsu Caymaz, Alpay Ari |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Hepatitis B virus medicine.medical_specialty HBsAg medicine.disease_cause Gastroenterology Virus 03 medical and health sciences Hepatitis B Chronic 0302 clinical medicine Internal medicine Humans Medicine Hepatitis B e Antigens Retrospective Studies Hepatitis Hepatitis B Surface Antigens business.industry Incidence (epidemiology) virus diseases Retrospective cohort study General Medicine Hepatitis B medicine.disease Virology digestive system diseases 030104 developmental biology DNA Viral 030211 gastroenterology & hepatology business Viral load |
| Zdroj: | Volume: 46, Issue: 1 48-52 Turkish Journal of Medical Sciences |
| ISSN: | 1303-6165 1300-0144 |
| Popis: | The incidence and predictors of spontaneous hepatitis B surface-antigen (HBsAg) seroclearance in patients with chronic hepatitis B virus (HBV) were evaluated.A total of 1427 patients with chronic HBV infection, who were followed between 1994 and 2013, were investigated in this retrospective study. All data were extracted from patient files.Spontaneous HBsAg seroclearance occurred in 84 patients during 8798 person-years of follow-up. The patients were categorized into 3 groups at follow-up based on HBV DNA features as continuously100 copies/mL (Group A), 0-10,000 copies/mL (Group B), and 0 to10,000 copies/mL (Group C). Alanine aminotransferase features in the 2 groups were categorized as continuously normal (40 U/L) and 0 to40 U/L. Spontaneous HBsAg seroclearance was seen primarily in patients with Group A HBV DNA features, and continuously low HBV DNA values were the main predictor of HBsAg seroclearance (P0.001).These results suggest that a continuously low viral load is the most important factor affecting spontaneous HBsAg seroclearance. |
| Databáze: | OpenAIRE |
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