Studying the effect of systemic and biological drugs on intima-media thickness in patients suffering from moderate and severe psoriasis
| Autor: | Gonzalo Blasco-Morente, Antonio Martínez-López, S. Arias-Santiago, Jesús Tercedor-Sánchez, I. Pérez-López |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Dermatology Carotid Intima-Media Thickness Severity of Illness Index Gastroenterology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Psoriasis Diabetes mellitus Internal medicine Ustekinumab Severity of illness medicine Humans Insulin Longitudinal Studies Prospective Studies cardiovascular diseases Prospective cohort study 030203 arthritis & rheumatology Biological Products Tumor Necrosis Factor-alpha business.industry Arteriosclerosis Middle Aged medicine.disease Lipoproteins LDL Methotrexate Infectious Diseases Intima-media thickness cardiovascular system Female Dermatologic Agents Tunica Intima Tunica Media business medicine.drug |
| Zdroj: | Journal of the European Academy of Dermatology and Venereology. 32:1492-1498 |
| ISSN: | 0926-9959 |
| DOI: | 10.1111/jdv.14841 |
| Popis: | Background Psoriasis has been related to a large number of cardiovascular risk factors such as hypertension, diabetes mellitus and arteriosclerosis. The increased carotid intima-media thickness (IMT) could be considered to be a marker of generalized arteriosclerosis. Objective To assess the effect of systemic and biological drugs on psoriatic patients' carotid IMT. Methods A prospective study was performed. We studied 53 patients with moderate and severe psoriasis from our psoriasis dermatological unit, analysing lipid and glucose metabolism and performing a carotid IMT sonography before introduction of systemic and biological drugs. After that, we performed an 8-month closely analytic and sonographic follow-up. Results The IMT of the patients with psoriasis treated with biological drugs tended to decrease, although this occurrence was not statistically significant (P = 0.086). The subgroup analysis revealed that patients treated with methotrexate (P = 0.045) and anti-IL-12/23 (P = 0.010) presented a decrease in their IMT levels. This analysis also showed a decrease in glycaemia and insulin levels in patients treated with TNF-alpha inhibitors and ustekinumab. Conclusions Our study suggests that the carotid IMT may benefit from treatment with biological drugs, particularly anti-IL-12/23 and methotrexate in patients suffering from moderate and severe psoriasis. However, larger longitudinal studies should be performed to fully confirm these results. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text