Garcinia cambogia, Either Alone or in Combination With Green Tea, Causes Moderate to Severe Liver Injury
| Autor: | Hans L. Tillmann, Herbert L. Bonkovsky, David E. Kleiner, Jose Serrano, Leonard B. Seeff, Jay H. Hoofnagle, Ikhlas A. Khan, Jawad Ahmad, Elizabeth J. Phillips, Francisco Durazo, Robert J. Fontana, Victor J. Navarro, Christopher Koh, Jiezhun Gu, Huiman X. Barnhart, Andrew Stolz, Don C. Rockey, Yi-Ju Li, Raj Vuppalanchi |
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| Rok vydání: | 2022 |
| Předmět: |
Moderate to severe
medicine.medical_specialty Garcinia cambogia medicine.medical_treatment Liver transplantation Gastroenterology Article chemistry.chemical_compound Weight loss Internal medicine Humans Medicine Liver injury Tea Hepatology business.industry Jaundice medicine.disease Green tea Hydroxycitric acid chemistry HLA-B Antigens Dietary Supplements Chemical and Drug Induced Liver Injury medicine.symptom business |
| Zdroj: | Clin Gastroenterol Hepatol |
| ISSN: | 1542-3565 |
| Popis: | BACKGROUND: Garcinia cambogia, either alone or with green tea, is commonly promoted for weight loss. Sporadic cases of liver failure from G. cambogia have been reported, but its role in liver injury is controversial. METHODS: Among 1418 patients enrolled in the Drug-Induced Liver Injury Network (DILIN) from 2004 to 2018, we identified 22 cases (adjudicated with high confidence) of liver injury from G. cambogia either alone (n=5) or in combination with green tea (n=16) or Ashwagandha (n=1). Control groups consisted of 57 patients with liver injury from herbal and dietary supplements (HDS) containing green tea without G. cambogia and 103 patients from other HDS. RESULTS: Patients who took G. cambogia were between 17 to 54 years, with liver injury arising 13 to 223 days (median = 51) after the start. One patient died, one required liver transplantation, and 91% were hospitalized. The liver injury was hepatocellular with jaundice. Although the peak values of aminotransferases were significantly higher (2001 ± 1386 U/L) in G. cambogia group (p |
| Databáze: | OpenAIRE |
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