Itraconazole or allopurinol in the treatment of chronic American trypanosomiasis: the results of clinical and parasitological examinations 11 years post-treatment
| Autor: | Arribada A, Gina Sánchez, Luis Carlos Gil, Aldo Solari, K. Mundaca, Werner Apt, Inés Zulantay, Antonio Osuna, Jose A. Rodriguez, Ximena Coronado |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Chagas disease medicine.medical_specialty Pathology Itraconazole Allopurinol Trypanosoma cruzi Polymerase Chain Reaction Gastroenterology Electrocardiography Double-Blind Method Internal medicine parasitic diseases Triatoma infestans medicine Animals Humans Chagas Disease Adverse effect biology Arrhythmias Cardiac DNA Protozoan Middle Aged medicine.disease biology.organism_classification Xenodiagnosis Infectious Diseases Chronic Disease Female Parasitology Trypanosomiasis Follow-Up Studies medicine.drug |
| Zdroj: | ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY Artículos CONICYT CONICYT Chile instacron:CONICYT |
| ISSN: | 1364-8594 0003-4983 |
| DOI: | 10.1179/136485905x75403 |
| Popis: | Eleven years after they had been given itraconazole or allopurinol for the treatment of chronic American trypanosomiasis, 109 adult patients were checked for electrocardiographic abnormalities and evidence of Trypanosoma cruzi infection. The parasitological investigations included xenodiagnosis, in which the faeces of Triatoma infestans that had fed on the patients were checked under the microscope for flagellates. In addition, a PCR-based assay and a hybridization assay were used to test blood samples from the patients, and faeces from the Tri. infestans that had fed on the patients, for Try. cruzi DNA. For the data analysis, the patients were divided into four groups known as normal/normal, abnormal/normal, normal/abnormal and abnormal/abnormal, according to whether the patients had been found to have normal or abnormal electrocardiograms (ECG) shortly before the first treatment and to have normal or abnormal ECG when checked at the 11-year follow-up. The 51 normal/normal and 24 normal/abnormal patients were assumed to have been in the 'indeterminate' phase of the disease when they were treated, whereas the 16 abnormal/normal and 18 abnormal/abnormal patients all had evidence of chagasic cardiopathy at that time. When checked 11 years post-treatment, 40 (78.4%), 17 (70.8%), 14 (87.5%) and 17 (94.4%) of these patients, respectively, were each found positive for Try. cruzi in at least one of the parasitological tests. The hybridization assay, whether applied to human blood or bug faeces, appeared a significantly more sensitive test than the PCR-based assays or microscopically assessed xenodiagnosis (P |
| Databáze: | OpenAIRE |
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