THE CORRELATION OF SERUM IMMUNOGLOBULIN FREE LIGHT CHAIN LEVELS AND SELECTED BIOLOGICAL MARKERS IN MULTIPLE MYELOMA
| Autor: | Marie Budíková, Tomas Pika, Pavel Lochman, Petr Schneiderka, Vlastimil Scudla, Vera Farbiakova, Jaroslav Bacovsky, Katerina Langova, Jiri Minarik |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Population Immunoglobulin light chain General Biochemistry Genetics and Molecular Biology Correlation Prohibitins Biomarkers Tumor medicine Humans education Multiple myeloma Aged Aged 80 and over education.field_of_study biology Chemistry Beta-2 microglobulin Middle Aged medicine.disease Free Light Chain Molecular biology Immunology biology.protein Female Immunoglobulin Light Chains Antibody Multiple Myeloma Kappa |
| Zdroj: | Biomedical Papers. 152:61-64 |
| ISSN: | 1804-7521 1213-8118 |
| DOI: | 10.5507/bp.2008.009 |
| Popis: | Aims: the presented study is aimed at the evaluation of correlation of free light chains serum levels – kappa, lambda and their relation (K/L ratio) and serum levels of selected biological markers in a group of patients with multiple myeloma examined at the time of the diagnosis. Methods: 102 patients with multiple myeloma were included in this prospective study. Free light chains serum levels were determined by Freelite TM Binding Site system, for determination of serum levels of selected parameters the following methods were used: REA thymidinekinase (TK), RIA (β 2 microglobulin (β 2 m), ICTP, PINP), enzymoimmunoassay (sIL-6R, sVCAM-1, sICAM-1, sOPG) and quantitative enzymatic immunoassay (sHGF, sVEGF, sSyndecan-1 (sSyn-1) a sFas). Results: There was found a correlation in the kappa-group of the dominant kappa chain and serum readings of β 2 m (r = 0.344, p = 0.005), TK (r = 0.263, p = 0.035), ICTP (r = 0.402, p = 0.001), PINP (r = 0.264, p = 0.039), sOPG (r = 0.328, p = 0.028), sSyn-1 (r = 0.255, p = 0.046) and sFas (r = 0.418, p = 0.001). In case of K/L ratio there was found a statistically signifi cant association of levels of β 2 m (r = 0.316, p = 0.01), TK (r = 0.274, p = 0.027), ICTP (r = 0.346, p = 0.006), PINP (r = 0.261, p = 0.042), sSyn-1 (r = 0.283, p = 0.026) and sFas (r = 0.377, p = 0.002). In the lambda-group the analysis confi rmed mutual dependence of the dominant lambda chain levels on β 2 m (r = 0.476, p = 0.003), ICTP (r = 0.375, p = 0.022), sVCAM-1 (r = 0.383, p = 0.019), sHGF (r = 0.441, p = 0.006) and sFas (r = 0.334, p = 0.040). In addition we ascertained a correlation of L/K ratio and levels of β 2 m (r = –0.473, p = 0.003), TK (r = –0.412, p = 0.011), ICTP (r = –0.331, p = 0.045), PINP (r = –0.409, p = 0.012), sHGF (r = –0.357, p = 0.028), sSyn-1 (r = –0.449, p = 0.005) a sFas (r = – 0.371, p = 0.022). Conclusions: The study confi rmed mutual correlation of FLC serum levels and the levels of several selected biological markers, in particular β 2 m, TK, ICTP, PINP, sSyn-1 a sFas at time of the diagnosis. It referred to the mutual relation of bone marrow microenvironment, biological qualities of clonal plasmocytes and the intensity of the free light chains production by the tumour cell population. |
| Databáze: | OpenAIRE |
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