Coenzyme Q10 Reduces β-Amyloid Plaque in an APP/PS1 Transgenic Mouse Model of Alzheimer’s Disease
| Autor: | Geng Li, Edward S. Yang, George Dai, Xifei Yang |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Genetically modified mouse Pathology medicine.medical_specialty Amyloid Ubiquinone Transgene BACE1-AS Mice Transgenic Plaque Amyloid Biology Hippocampus Presenilin Mice Cellular and Molecular Neuroscience chemistry.chemical_compound Alzheimer Disease Presenilin-1 medicine Amyloid precursor protein Animals Humans Cerebral Cortex Coenzyme Q10 Amyloid beta-Peptides Vitamins General Medicine Magnetic Resonance Imaging Disease Models Animal Neuroprotective Agents chemistry biology.protein Cancer research Intracellular |
| Zdroj: | Journal of Molecular Neuroscience. 41:110-113 |
| ISSN: | 1559-1166 0895-8696 |
| DOI: | 10.1007/s12031-009-9297-1 |
| Popis: | We previously reported that coenzyme Q10 (CoQ10) could reduce intracellular deposition in an aged transgenic mouse model. Here, we further tested the effect of CoQ10 on amyloid plaque in an amyloid precursor protein/presenilin 1 transgenic mouse model of Alzheimer's disease (AD). By using immunohistochemistry and magnetic resonance imaging to determine the burden of amyloid plaque, we found that oral administration of CoQ10 can efficiently reduce the burden of the plaques in this mouse model. These data demonstrate that in addition to reducing intracellular deposition of Abeta, CoQ10 can also reduce plaque pathology. Our study further supports the use of CoQ10 as a therapeutic candidate for AD. |
| Databáze: | OpenAIRE |
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