Intraventricular pressure gradients change during the development of left ventricular hypertrophy: Effect of salvianolic acid B and beta-blocker
| Autor: | Ahmed S. Mandour, Tomohiko Yoshida, Ryou Tanaka, Akiko Uemura, Ken Takahashi, Mayumi Ifuku, Katsuhiro Matsuura, Kazumi Shimada, Pitipat Kitpipatkun, Danfu Ma |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Salvianolic acid B Radiological and Ultrasound Technology medicine.diagnostic_test medicine.drug_class business.industry 030204 cardiovascular system & hematology Doppler echocardiography Left ventricular hypertrophy medicine.disease 03 medical and health sciences 0302 clinical medicine Internal medicine Intraventricular pressure Cardiology medicine Radiology Nuclear Medicine and imaging Diastolic function business Beta blocker 030217 neurology & neurosurgery Pressure gradient Original Research |
| Zdroj: | Ultrasound |
| ISSN: | 1743-1344 1742-271X |
| DOI: | 10.1177/1742271x20987584 |
| Popis: | Introduction Intraventricular pressure gradient is regarded as a non-invasive indicator of diastolic function. Salvianolic acid B (Sal-B), a traditional Asian medicine, revealed its usefulness in myocardial infarction models; however, the hemodynamic effect of salvianolic acid B is still unknown. The present study aimed to investigate the intraventricular pressure gradient changes during the development of left ventricular hypertrophy with or without salvianolic acid B and a beta-blocker. Methods In total, 48 rats were divided into four groups; Sham, Non-treatment, salvianolic acid B, and Carvedilol. Aortic coarctation-induced left ventricular hypertrophy was done in three groups and the treatment was started from the third to the sixth week. Blood pressure, conventional echocardiography, and color M-mode echocardiography for measurement of intraventricular pressure gradient were carried out for six consecutive weeks. Results At 4.5 weeks, the LV mass was elevated in the coarctation groups but the blood pressure was significantly lower in salvianolic acid B and Carvedilol groups ( P Conclusions Salvianolic acid B and Carvedilol promote cardiac function by decreasing the elevated basal intraventricular pressure gradient. The current preclinical results revealed the efficacy of salvianolic acid B as a potential therapy for left ventricular hypertrophy because of the non-blood pressure lowering effect. |
| Databáze: | OpenAIRE |
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