Review of Chromatographic Bioanalytical Assays for the Quantitative Determination of Marine-Derived Drugs for Cancer Treatment

Autor: van Andel, Lotte, Rosing, Hilde, Schellens, Jan Hm, Beijnen, Jos H, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology
Přispěvatelé: Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Drug
Bioanalysis
marine-derived drugs
Aquatic Organisms
media_common.quotation_subject
bioanalysis
Pharmaceutical Science
Antineoplastic Agents
Review
Drug levels
03 medical and health sciences
0302 clinical medicine
Pharmacokinetics
Neoplasms
Drug Discovery
Antineoplastic Agents/chemistry
medicine
Sample Type
cancer
Animals
Humans
Aquatic Organisms/chemistry
Drug Discovery/methods
lcsh:QH301-705.5
Pharmacology
Toxicology and Pharmaceutics (miscellaneous)
Biological Assay/methods
media_common
Chromatography
business.industry
Chromatography
Liquid/methods
Cancer
medicine.disease
Quantitative determination
Cancer treatment
Neoplasms/drug therapy
030104 developmental biology
lcsh:Biology (General)
030220 oncology & carcinogenesis
Liquid/methods
Biological Assay
business
Chromatography
Liquid
Zdroj: Marine Drugs
Marine Drugs, 16(7). Multidisciplinary Digital Publishing Institute (MDPI)
Marine Drugs, Vol 16, Iss 7, p 246 (2018)
ISSN: 1660-3397
Popis: The discovery of marine-derived compounds for the treatment of cancer has seen a vast increase over the last few decades. Bioanalytical assays are pivotal for the quantification of drug levels in various matrices to construct pharmacokinetic profiles and to link drug concentrations to clinical outcomes. This review outlines the different analytical methods that have been described for marine-derived drugs in cancer treatment hitherto. It focuses on the major parts of the bioanalytical technology, including sample type, sample pre-treatment, separation, detection, and quantification.
Databáze: OpenAIRE
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