Respiratory-induced errors in tumor quantification and delineation in CT attenuation-corrected PET images: effects of tumor size, tumor location, and respiratory trace: a simulation study using the 4D XCAT phantom
| Autor: | Mojtaba Shamsaie Zafarghandi, Mohammad Reza Ay, Arman Rahmim, Pardis Ghafarian, Parham Geramifar |
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| Rok vydání: | 2013 |
| Předmět: |
Cancer Research
medicine.medical_specialty Lung Neoplasms Movement Standardized uptake value Models Biological Imaging phantom Lesion Imaging Three-Dimensional medicine Humans Radiology Nuclear Medicine and imaging Computer Simulation Respiratory system PET-CT medicine.diagnostic_test business.industry Phantoms Imaging Liver Neoplasms Exhalation Oncology Positron emission tomography Positron-Emission Tomography Respiratory Mechanics Radiology medicine.symptom business Nuclear medicine Artifacts Tomography X-Ray Computed Correction for attenuation |
| Zdroj: | Molecular imaging and biology. 15(6) |
| ISSN: | 1860-2002 |
| Popis: | Purpose: We investigated the magnitude of respiratory-induced errors in tumor maximum standardized uptake value (SUVmax), localization,and volume for differentrespiratory motion traces and various lesion sizes in different locations of the thorax and abdomen in positron emission tomography (PET) images. Procedures: Respiratory motion traces were simulated based on the common patient breathing cycle and three diaphragm motions used to drive the 4D XCAT phantom. Lesions with different diameters were simulated in different locations of lungs and liver. The generated PET sinograms were subsequently corrected using computed tomography attenuation correction involving the end exhalation, end inhalation, and average of the respiratory cycle. By considering respirationaveraged computed tomography as a true value, the lesion volume, displacement, and SUVmax were measured and analyzed for different respiratory motions. Results: Respirationwith35-mmdiaphragmmotionresultsinameanlesionSUVmaxerrorof 24%,a mean superior inferior displacement of 7.6 mm and a mean lesion volume overestimation of 129 % fora9-mmlesionintheliver.Respiratorymotionresultsinlesionvolumeoverestimationof50%fora 9-mm lower lung lesion near the liver with just 15-mm diaphragm motion. Although there are larger errors in lesion SUVmax and volume for 35-mm motion amplitudes, respiration-averaged computed tomography results in smaller errors than the other two phases, except for the lower lung region. Conclusions: The respiratory motion-induced errors in tumor quantification and delineation are highly dependent upon the motion amplitude, tumor location, tumor size, and choice of the attenuation map for PET image attenuation correction. |
| Databáze: | OpenAIRE |
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