Determinants of renal tissue oxygenation as measured with BOLD-MRI in chronic kidney disease and hypertension in humans
| Autor: | Carole Zweiacker, Menno Pruijm, Bruno Vogt, Lucie Hofmann, Michel Burnier, Marie Eve Muller, Matthias Stuber, Maciej Piskunowicz, Isabelle Bassi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
lcsh:Medicine Blood Pressure Kidney urologic and male genital diseases Vascular Medicine Diagnostic Radiology chemistry.chemical_compound Furosemide Chronic Kidney Disease Medicine and Health Sciences Diuretics 610 Medicine & health lcsh:Science Kidney Medulla Multidisciplinary Applied Mathematics Radiology and Imaging Hematology Middle Aged Magnetic Resonance Imaging Cell Hypoxia medicine.anatomical_structure Nephrology Hypertension Physical Sciences Administration Intravenous Female Statistics (Mathematics) medicine.drug Research Article Adult medicine.medical_specialty Kidney Cortex Cardiology Renal function Biostatistics Oxygen Consumption Diagnostic Medicine Diabetes mellitus Internal medicine medicine Humans Renal Insufficiency Chronic Aged business.industry lcsh:R Hemodynamics Oxygenation medicine.disease Oxygen Blood pressure Endocrinology chemistry Case-Control Studies Uric acid 570 Life sciences biology lcsh:Q business Mathematics Kidney disease |
| Zdroj: | PLoS ONE, Vol 9, Iss 4, p e95895 (2014) PLoS ONE PLOS One Plos One, vol. 9, no. 4, pp. e95895 Pruijm, Menno; Hofmann, Lucie; Piskunowicz, Maciej; Muller, Marie-Eve; Zweiacker, Carole; Bassi, Isabelle; Vogt, Bruno; Stuber, Matthias; Burnier, Michel (2014). Determinants of renal tissue oxygenation as measured with BOLD-MRI in chronic kidney disease and hypertension in humans. PLoS ONE, 9(4), e95895. Public Library of Science 10.1371/journal.pone.0095895 PLoS One |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0095895 |
| Popis: | Experimentally renal tissue hypoxia appears to play an important role in the pathogenesis of chronic kidney disease (CKD) and arterial hypertension (AHT). In this study we measured renal tissue oxygenation and its determinants in humans using blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) under standardized hydration conditions. Four coronal slices were selected, and a multi gradient echo sequence was used to acquire T2* weighted images. The mean cortical and medullary R2* values ( = 1/T2*) were calculated before and after administration of IV furosemide, a low R2* indicating a high tissue oxygenation. We studied 195 subjects (95 CKD, 58 treated AHT, and 42 healthy controls). Mean cortical R2 and medullary R2* were not significantly different between the groups at baseline. In stimulated conditions (furosemide injection), the decrease in R2* was significantly blunted in patients with CKD and AHT. In multivariate linear regression analyses, neither cortical nor medullary R2* were associated with eGFR or blood pressure, but cortical R2* correlated positively with male gender, blood glucose and uric acid levels. In conclusion, our data show that kidney oxygenation is tightly regulated in CKD and hypertensive patients at rest. However, the metabolic response to acute changes in sodium transport is altered in CKD and in AHT, despite preserved renal function in the latter group. This suggests the presence of early renal metabolic alterations in hypertension. The correlations between cortical R2* values, male gender, glycemia and uric acid levels suggest that these factors interfere with the regulation of renal tissue oxygenation. |
| Databáze: | OpenAIRE |
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