The Functional Val158Met Polymorphism ofCOMTPredicts Interindividual Differences in Brain α Oscillations in Young Men
| Autor: | Roland Dürr, Hans-Peter Landolt, Eva Geissler, Claudia Stoll, Sereina Bodenmann, Thomas Rusterholz, Karin Jaggi-Schwarz, Valérie Bachmann |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Sleep Wake Disorders medicine.medical_specialty Alpha (ethology) Modafinil Electroencephalography Catechol O-Methyltransferase Young Adult Methionine Predictive Value of Tests Internal medicine medicine Humans Prospective Studies Benzhydryl Compounds Wakefulness Prefrontal cortex Cross-Over Studies Polymorphism Genetic medicine.diagnostic_test General Neuroscience Dopaminergic Age Factors Valine Articles Sleep in non-human animals Alpha Rhythm Sleep deprivation Endocrinology medicine.symptom Psychology Neuroscience medicine.drug |
| Zdroj: | The Journal of Neuroscience. 29:10855-10862 |
| ISSN: | 1529-2401 0270-6474 |
| Popis: | Individual patterns of the electroencephalogram (EEG) in wakefulness and sleep are among the most heritable traits in humans, yet distinct genetic and neurochemical mechanisms underlying EEG phenotypes are largely unknown. A functional polymorphism in the gene encoding catechol-O-methyltransferase (COMT), an enzyme playing an important role in cortical dopamine metabolism, causes a common substitution of methionine (Met) for valine (Val) at codon 158 of COMT protein. Val allele homozygotes exhibit higher COMT activity and lower dopaminergic signaling in prefrontal cortex than Met/Met homozygotes. Evidence suggests that this polymorphism affects executive functions in healthy individuals. We hypothesized that it also modulates functional aspects of EEG in wakefulness and sleep. EEG recordings were conducted twice on separate occasions in 10 Val/Val and 12 Met/Met allele carriers (all men) in wakefulness, and in baseline and recovery sleep before and after 40 h prolonged waking. During sleep deprivation, subjects received placebo and modafinil in randomized, cross-over manner. We show that the Val158Met polymorphism predicts stable and frequency-specific, interindividual variation in brain α oscillations. α peak frequency in wakefulness was 1.4 Hz slower in Val/Val genotype than in Met/Met genotype. Moreover, Val/Val allele carriers exhibited less 11–13 Hz activity than Met/Met homozygotes in wakefulness, rapid-eye-movement (REM) sleep, and non-REM sleep. This difference was resistant against the effects of sleep deprivation and modafinil. The data demonstrate that mechanisms involving COMT contribute to interindividual differences in brain α oscillations, which are functionally related to executive performance such as counting tendency on a random number generation task in young adults. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|