Inflammation-Related Risk Loci in Genome-Wide Association Studies of Coronary Artery Disease
| Autor: | Carina Mauersberger, Heribert Schunkert, Hendrik B. Sager |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Risk Inflammation Context (language use) Genome-wide association study Review Computational biology Disease Coronary Artery Disease 030204 cardiovascular system & hematology Coronary artery disease 03 medical and health sciences 0302 clinical medicine Medicine Humans genetics lcsh:QH301-705.5 Genetic association business.industry General Medicine medicine.disease 030104 developmental biology lcsh:Biology (General) genome-wide association studies medicine.symptom atherosclerosis business Genome-Wide Association Study |
| Zdroj: | Cells, Vol 10, Iss 440, p 440 (2021) Cells |
| ISSN: | 2073-4409 |
| Popis: | Although the importance of inflammation in atherosclerosis is now well established, the exact molecular processes linking inflammation to the development and course of the disease are not sufficiently understood. In this context, modern genetics—as applied by genome-wide association studies (GWAS)—can serve as a comprehensive and unbiased tool for the screening of potentially involved pathways. Indeed, a considerable proportion of loci discovered by GWAS is assumed to affect inflammatory processes. Despite many well-replicated association findings, however, translating genomic hits to specific molecular mechanisms remains challenging. This review provides an overview of the currently most relevant inflammation-related GWAS findings in coronary artery disease and explores their potential clinical perspectives. |
| Databáze: | OpenAIRE |
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