Modifications in the concentrations of circulating myoglobin after treatment with low doses of Adriamycin
| Autor: | Giovanni Carulli, Antonio Azzara, Maria Grazia Del Chicca, Fabio Ambrogi, Aldo Clerico, Alessandra Marini, Bruno Grassi, Renato Vanacore |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1985 |
| Předmět: |
Adult
Male 030213 general clinical medicine Cancer Research medicine.medical_specialty Biorhythm 030204 cardiovascular system & hematology Creatine Injections Intramuscular 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Humans Skeletal muscle damage Creatine Kinase Aged Myoglobin Chemistry Low dose Heart Radioimmunoassay General Medicine Middle Aged Endocrinology Oncology Doxorubicin Female After treatment |
| Popis: | The modifications in the concentration of circulating myoglobin have been studied by means of a radioimmunoassay in 15 cancer patients undergoing polychemotherapy including adriamycin. In 8 patients significant increases in myoglobin levels were found after injection of low doses of the drug (25-50 mg/m2). Moreover, a disturbance of the normal biorhythm of the protein was evident in 12 patients. Creatine kinase-MB was evaluated by means of a radioimmunoassay, but there was no relation between an increase in the isoenzyme and an increase in myoglobin. No ECG modifications were detected. These data indicate that the measurement of myoglobin may offer an indication of myocardial or skeletal muscle damage caused by adriamycin. |
| Databáze: | OpenAIRE |
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