A network for computing value homeostasis in the human medial prefrontal cortex
| Autor: | María Ruz, Keno Juechems, Jan Balaguer, Jill X. O’Reilly, Christopher Summerfield, Santiago Herce Castañón |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0303 health sciences
medicine.diagnostic_test Ventromedial prefrontal cortex 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure medicine Biological neural network Asset (economics) Functional magnetic resonance imaging Prefrontal cortex Psychology Value (mathematics) Neuroscience 030217 neurology & neurosurgery Homeostasis Anterior cingulate cortex health care economics and organizations 030304 developmental biology |
| DOI: | 10.1101/278531 |
| Popis: | Humans and other animals make decisions in order to satisfy their goals. However, it remains unknown how neural circuits compute which of multiple possible goals should be pursued (e.g. when balancing hunger and thirst) and combine these signals with estimates of available reward alternatives. Here, humans undergoing functional magnetic resonance imaging (fMRI) accumulated two distinct assets over a sequence of trials. Financial outcomes depended on the minimum cumulate of either asset, creating a need to maintain “value homeostasis” by redressing any imbalance among the assets. BOLD signals in the dorsal anterior cingulate cortex (dACC) tracked the level of homeostatic imbalance among goals, whereas the ventromedial prefrontal cortex (vmPFC) signalled the level of homeostatic redress incurred by a choice, rather than the overall amount received. These results suggest that a network of medial frontal brain regions compute a value signal that maintains homeostatic balance among internal goals. |
| Databáze: | OpenAIRE |
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