Regulation of MicroRNAs in Inflammation-Associated Colorectal Cancer: A Mechanistic Approach
| Autor: | Gautam Chaudhuri, Yuvaraj Sambandam, Satish Ramalingam, Lurdes Queimado, Sneha Krishnamoorthy, Ileng Kumaran Ramachandran, Ilangovan Ramachandran, Sridhar Muthusami |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Colorectal cancer Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism medicine.disease_cause Inflammatory bowel disease Metastasis Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine microRNA Animals Humans Immunology and Allergy Medicine Inflammation business.industry Colitis Inflammatory Bowel Diseases medicine.disease Ulcerative colitis digestive system diseases Gene Expression Regulation Neoplastic MicroRNAs Cell Transformation Neoplastic 030104 developmental biology Cancer research Tumor necrosis factor alpha Colorectal Neoplasms business Carcinogenesis Signal Transduction |
| Zdroj: | Endocrine, Metabolic & Immune Disorders - Drug Targets. 21:67-76 |
| ISSN: | 1871-5303 |
| DOI: | 10.2174/1871530320666200917112802 |
| Popis: | The development of colorectal cancer (CRC) is a multistage process. The inflammation of the colon as in inflammatory bowel disease (IBD) such as ulcerative colitis (UC) or Crohn’s disease (CD) is often regarded as the initial trigger for the development of inflammation-associated CRC. Many cytokines such as tumor necrosis factor alpha (TNF-α) and interleukins (ILs) are known to exert proinflammatory actions, and inflammation initiates or promotes tumorigenesis of various cancers, including CRC, through differential regulation of microRNAs (miRNAs/miRs). miRNAs can be oncogenic miRNAs (oncomiRs) or anti-oncomiRs/tumor suppressor miRNAs, and they play key roles during colorectal carcinogenesis. However, the functions and molecular mechanisms of regulation of miRNAs involved in inflammation-associated CRC are still anecdotal and largely unknown. Consolidating the published results and offering perspective solutions to circumvent CRC, the current review is focused on the role of miRNAs and their regulation in the development of CRC. We have also discussed the model systems adapted by researchers to delineate the role of miRNAs in inflammation-associated CRC. |
| Databáze: | OpenAIRE |
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