Predictors of Nodal and Metastatic Failure in Early Stage Non–small-cell Lung Cancer After Stereotactic Body Radiation Therapy
| Autor: | Tim Lautenschlaeger, Neil C. Estabrook, S. Freije, Jun Wan, Mark Langer, Ke Huang, Khalil Diab, Richard C. Zellars, Alberto Cerra-Franco, Donna Edwards, Kevin Shiue, Michella Azar, Susannah G. Ellsworth, Christopher R. Deig, Feng Ming Kong, J. Hinton, Sheng Liu |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Pulmonary and Respiratory Medicine Cancer Research medicine.medical_specialty Lung Neoplasms Stereotactic body radiation therapy Radiosurgery SABR volatility model Article Metastasis 03 medical and health sciences 0302 clinical medicine Risk Factors Carcinoma Non-Small-Cell Lung medicine Humans Treatment Failure Stage (cooking) Lung cancer Aged Neoplasm Staging Retrospective Studies Aged 80 and over Lung business.industry Proportional hazards model Radiotherapy Dosage Middle Aged Prognosis medicine.disease Tumor Burden 030104 developmental biology medicine.anatomical_structure Oncology Lymphatic Metastasis 030220 oncology & carcinogenesis Disease Progression Female Radiology business NODAL Follow-Up Studies |
| Zdroj: | Clin Lung Cancer |
| ISSN: | 1525-7304 |
| DOI: | 10.1016/j.cllc.2018.12.016 |
| Popis: | INTRODUCTION/BACKGROUND: Many early-stage non-small cell lung cancer (ES-NSCLC) patients undergoing stereotactic body radiation therapy (SBRT) develop metastases, which is associated with poor outcomes. We sought to identify factors predictive of metastases after lung SBRT and created a risk stratification tool. MATERIALS AND METHODS: We included 363 patients with ES-NSCLC who received SBRT; median follow-up was 5.8 years. The following patient and tumor factors were retrospectively analyzed for their association with metastases (defined as nodal and/or distant failure): sex; age; lobe involved; centrality; previous NSCLC; smoking status; gross tumor volume (GTV); T-stage; histology; dose; minimum, maximum, and mean GTV dose; and parenchymal lung failure. A metastasis risk-score linear-model using beta coefficients from a multivariate Cox model was built. RESULTS: A total of 111/406 (27.3%) lesions metastasized. GTV volume and dose were significantly associated with metastases on univariate and multivariate Cox proportional hazards modeling (p |
| Databáze: | OpenAIRE |
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