Photobiomodulation with low-level laser therapy reduces oral mucositis caused by head and neck radio-chemotherapy: prospective randomized controlled trial
| Autor: | M.A. Serrera-Figallo, Daniel Torres-Lagares, José-Luis Gutiérrez-Pérez, J. Pachón-Ibañez, Lizett Castellanos-Cosano, F. Marín-Conde |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oropharyngeal mucositis
medicine.medical_specialty medicine.medical_treatment Gastroenterology law.invention 03 medical and health sciences 0302 clinical medicine Double-Blind Method Randomized controlled trial law Internal medicine medicine Mucositis Humans Prospective Studies Low-Level Light Therapy Head and neck Adverse effect Low level laser therapy Aged Radio chemotherapy Stomatitis business.industry Incidence (epidemiology) 030206 dentistry Middle Aged medicine.disease Otorhinolaryngology Head and Neck Neoplasms 030220 oncology & carcinogenesis Carcinoma Squamous Cell Mouth Neoplasms Surgery Oral Surgery business |
| Zdroj: | International Journal of Oral and Maxillofacial Surgery. 48:917-923 |
| ISSN: | 0901-5027 |
| Popis: | The objective of this study was to assess the effectiveness of photobiomodulation with low-level laser therapy (LLLT) as a preventive and therapeutic procedure for the treatment of oral and oropharyngeal mucositis caused by radio-chemotherapy in patients diagnosed with oral squamous cell carcinoma (SCC). An experimental, prospective, double-blind, randomized controlled study was conducted involving patients diagnosed with oral SCC undergoing oncological treatment. The variables analyzed included grade, appearance, and remission of mucositis. A final sample of 26 patients was included: 11 (42.3%) in the study group and 15 (57.7%) in the control group; their average age was 60.89±9.99years. Statistically significant differences between the groups were observed from week 5 of oncological treatment; 72.7% of the laser group showed normal mucosa (mucositis grade 0), while in the control group, 20.0% showed grade 0 mucositis and 40.0% showed grade 2 mucositis (P0.01). No statistically significant difference between the groups was found regarding the application or use of medication throughout the study period (P0.05). The tolerance evaluation did not show any statistically significant difference between the groups regarding the occurrence of side effects or adverse events during the trial (P0.05). Photobiomodulation with LLLT reduces the incidence and severity of mucositis in patients treated with radiotherapy±chemotherapy. |
| Databáze: | OpenAIRE |
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