Alexithymia in Amyotrophic Lateral Sclerosis and Its Neural Correlates
| Autor: | Francis Eustache, Franck Doidy, Fausto Viader, Marie sonia Buhour, Béatrice Desgranges, Audrey Mondou, Laurence Carluer, Soumia Benbrika |
|---|---|
| Přispěvatelé: | Neuropsychologie et imagerie de la mémoire humaine (NIMH), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), U1077, U1077, Normandie Université (NU)-Normandie Université (NU)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2018 |
| Předmět: |
amyotrophic lateral sclerosis
medicine.medical_specialty Audiology lcsh:RC346-429 050105 experimental psychology 03 medical and health sciences Toronto Alexithymia Scale 0302 clinical medicine Alexithymia medicine 0501 psychology and cognitive sciences Neuropsychological assessment Amyotrophic lateral sclerosis 10. No inequality Prefrontal cortex lcsh:Neurology. Diseases of the nervous system cognitive function ComputingMilieux_MISCELLANEOUS Original Research emotional processing [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology medicine.diagnostic_test business.industry 05 social sciences Cognition medicine.disease Executive functions Neurology emotional awareness Neurology (clinical) alexithymia business [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology 030217 neurology & neurosurgery Executive dysfunction |
| Zdroj: | Frontiers in Neurology Frontiers in Neurology, Frontiers, In press, ⟨10.3389/fneur.2018.00566⟩ Frontiers in Neurology, Vol 9 (2018) |
| ISSN: | 1664-2295 |
| DOI: | 10.3389/fneur.2018.00566 |
| Popis: | Introduction: Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease that causes progressive and extensive motor deficits. Patients may also have cognitive impairments or alteration of emotional processing. Very few studies, however, have looked at deficits in how they experience their own feelings (alexithymia). Methods: We assessed alexithymia in 28 patients with ALS using the 20-item Toronto Alexithymia Scale (TAS-20), comparing them with a control group matched for sex, age, and education level. We took into account both the total score of the TAS-20 and its three subscores corresponding to the three dimensions of alexithymia: Difficulty Identifying Feelings (DIF), Difficulty Describing Feelings (DDF), and Externally Oriented Thinking (EOT). Patients also underwent a neuropsychological assessment and anatomical magnetic resonance imaging (MRI) in order to correlate cognitive performances and gray matter volume and level of alexithymia. Results: On average, ALS subjects had a significantly higher total score and DIF sub-score of the TAS-20 than controls indicating an increased alexithymia in patients. Total and DIF Scores correlated significantly and negatively to gray matter volume of the prefrontal cortex, right superior temporal pole and parahippocampal gyri. No correlations were found between scores on executive functions and those on the TAS-20. Conclusion: The first stage of one's own emotional processing seems to be affected in ALS independently of executive dysfunction. This trouble seems to be underpinned by cerebral regions that are well known to be both implicated in alexithymia in healthy subjects and altered in ALS. |
| Databáze: | OpenAIRE |
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