Incidence of Interval Colorectal Cancer After Negative Results From First-Round Fecal Immunochemical Screening Tests, by Cutoff Value and Participant Sex and Age
| Autor: | Christian Ramakers, Marieke A.M. Frasa, Annemieke W.J. Opstal-van Winden, Gerrit A. Meijer, Ernst J. Kuipers, W.M.U. Van Grevenstein, Tj. Wiersma, Iris Lansdorp-Vogelaar, Harry J. de Koning, Geraldine R. Vink, Esther Toes-Zoutendijk, Evelien Dekker, J.A. Otte, Iris D. Nagtegaal, A. van der Beek, J. van Bergeijk, Marie-Louise F. van Velthuysen, L.H.J. Jacobs, E. J. R. de Graaf, Ad A.M. Masclee, Marloes A. G. Elferink, Folkert J. van Kemenade, Manon C.W. Spaander, Arthur I. Kooyker, Marjolein van Ballegooijen, Harriët van Veldhuizen, Monique E. van Leerdam, Jaap Stoker, Maarten Thomeer, Anneke J van Vuuren, Maaike Buskermolen |
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| Přispěvatelé: | Public Health, Gastroenterology & Hepatology, Clinical Chemistry, Pathology, Radiology & Nuclear Medicine, Gastroenterology and Hepatology, AGEM - Re-generation and cancer of the digestive system, CCA - Imaging and biomarkers, CCA - Cancer Treatment and Quality of Life, Amsterdam Gastroenterology Endocrinology Metabolism, APH - Quality of Care |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Colorectal cancer Population Gastroenterology 03 medical and health sciences Feces 0302 clinical medicine SDG 3 - Good Health and Well-being Internal medicine Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14] Medicine Cutoff Humans Mass Screening Cumulative incidence Interval Cancer Fecal Immunochemical Testing education Early Detection of Cancer Aged education.field_of_study Hepatology Colon Cancer business.industry Incidence (epidemiology) Incidence Colonoscopy medicine.disease Confidence interval 030220 oncology & carcinogenesis Occult Blood Screening 030211 gastroenterology & hepatology Female business Colorectal Neoplasms Value (mathematics) Negative Results |
| Zdroj: | Clinical Gastroenterology and Hepatology, 18(7), 1493-1500. W.B. Saunders Clinical gastroenterology and hepatology, 18(7), 1493-1500. W.B. Saunders Ltd Clinical Gastroenterology and Hepatology, 18, 1493-1500 Clinical Gastroenterology and Hepatology, 18(7), 1493-1500. ELSEVIER SCIENCE INC Clinical Gastroenterology and Hepatology, 18, 7, pp. 1493-1500 |
| ISSN: | 1542-3565 |
| Popis: | Contains fulltext : 220797pub.pdf (Publisher’s version ) (Open Access) BACKGROUND & AIMS: We evaluated the incidence of interval cancers between the first and second rounds of colorectal cancer (CRC) screening with the FOB-Gold fecal immunochemical test (FIT), and the effects of different cutoff values and patient sex and age. METHODS: We collected data from participants in a population-based CRC screening program in the Netherlands who had a negative result from a first-round of FIT screening. We calculated the cumulative incidence of interval cancer after a negative result from a FIT and the sensitivity of the FIT for detection of CRC at a low (15 mug Hb/g feces) and high (47 mug Hb/g feces) cutoff value. RESULTS: Among the 485,112 participants with a negative result from a FIT, 544 interval cancers were detected; 126 were in the 111,800 participants with negative results from a FIT with the low cutoff value and 418 were in the 373,312 FIT participants with negative results from a FIT with the high cutoff value. The mean age of participants tested with the low cutoff value was 72.0 years and the mean age of participants tested the high cutoff value was 66.7 years. The age-adjusted 2-year cumulative incidence of interval cancer after a negative result from a FIT were 9.5 per 10,000 persons at the low cutoff value vs 13.8 per 10,000 persons at the high cutoff value (P < .005). The age-adjusted sensitivity of the FIT for CRC were 90.5% for the low cutoff value vs 82.9% for the high cutoff (P < .0001). The FIT identified men with CRC with 87.4% sensitivity and women with CRC with 82.6% sensitivity (P < .001). CONCLUSIONS: In an analysis of data from a FIT population-based screening program in the Netherlands, we found that incidence of interval CRC after a negative result from a FIT to be low. Although the sensitivity of detection of CRC decreased with a higher FIT cutoff value, it remained above 80%. |
| Databáze: | OpenAIRE |
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