Biochemical, hematological and histopathological evaluation of the toxicity potential of the leaf extract of Stachytarpheta cayennensis in rats
| Autor: | Michael Oluwatoyin Daniyan, Oladotun A. Olayode, Gbola Olayiwola |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Stachytarpheta cayennensis
Central nervous system 0211 other engineering and technologies Physiology lcsh:Medicine 02 engineering and technology 01 natural sciences Diabetes mellitus 021105 building & construction Medicine Kidney Acute toxicity biology business.industry Histopathological analysis lcsh:R Repeated dose toxicity medicine.disease biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry Organotoxicity medicine.anatomical_structure Complementary and alternative medicine Repeated doses Safety assessment Toxicity Stachytarpheta cayennesis business |
| Zdroj: | Journal of Traditional and Complementary Medicine, Vol 10, Iss 6, Pp 544-554 (2020) |
| ISSN: | 2225-4110 |
| Popis: | Background and Aim: The many pharmacological potentials of Stachytarpheta cayennensis (L.C. Rich) Vahl, especially in managing central nervous system disorders, hypertension, diabetes and infections, have made it a subject of abuse, necessitating the need to ascertain its safety. This study therefore investigated the toxic effects of the leaf extract of S. cayennensis in rats following acute and 28-day repeated doses in male and female rats. Experimental procedure: Acute and repeated dose studies were conducted in male and female groups of rats (135–150 g), using OECD 423 and 407 Tests guidelines respectively. Functional observational battery, and body weights were monitored. Blood samples were analysed for haematological and plasma biochemical indices. Organs (brain, kidneys and liver) specimen were collected and weighed. Kidney and liver specimen were subjected to histopathological analysis. Results and conclusion: The LD50 of the extract was greater than 5000 mg/kg, p.o. (24 h) suggesting that the extract may be non-toxic. However, following single and repeated doses, the results revealed varying degree of significant (p |
| Databáze: | OpenAIRE |
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