Indium-111 antimyosin monoclonal antibody Fab imaging in patients with cardiomyopathy
| Autor: | Noriyoshi Umezaki, Toyofumi Wada, Satoshi Tanaka, Yoshinori Koga, Hironori Toshima, Naofumi Hayabuchi, Masatoshi Ishibashi, Seiichiro Morita |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Cardiomyopathy Dilated Male medicine.medical_specialty Necrosis Adolescent medicine.drug_class Systole Cardiomyopathy Myosins Monoclonal antibody Immunoglobulin Fab Fragments Diastole Internal medicine medicine Humans Radiology Nuclear Medicine and imaging In patient Heavy chain biology business.industry Indium Radioisotopes Cardiac myosin Antibodies Monoclonal Dilated cardiomyopathy Heart General Medicine Cardiomyopathy Hypertrophic Middle Aged medicine.disease Radioimmunodetection biology.protein Cardiology Female medicine.symptom Antibody business Cardiomyopathies |
| Zdroj: | Annals of nuclear medicine. 9(1) |
| ISSN: | 0914-7187 |
| Popis: | Six patients with cardiomyopathy were imaged following intravenous injection of an indium-111 labeled monoclonal antibody directed against the heavy chain of cardiac myosin. Two patients had hypertrophic non-obstructive cardiomyopathy (HNCM), two patients had dilated cardiomyopathy (DCM), and two patients had specific heart muscle disease. One of 2 patients with HNCM and one of 2 patients with DCM had a positive antimyosin scan. The 2 patients with specific heart muscle disease manifested persistent blood pool activity of the antibody, thereby precluding interpretation of the images. The present report demonstrates that antimyosin antibody imaging may provide evidence of myocardial injury, or necrosis in some patients with cardiomyopathy. |
| Databáze: | OpenAIRE |
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