Unliganded estrogen receptor alpha regulates vascular cell function and gene expression
| Autor: | Lakshmanan K. Iyer, Christine Briggs, Caroline S. Vallaster, Richard H. Karas, Qing Lu, Gavin R. Schnitzler, Iris Z. Jaffe, Stephanie Erdkamp, Kazutaka Ueda |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.drug_class Cell Myocytes Smooth Muscle Estrogen receptor Gene Expression Biology Biochemistry Muscle Smooth Vascular 03 medical and health sciences Mice Endocrinology Cell Movement Internal medicine Gene expression medicine Animals Molecular Biology Aorta Cells Cultured Cell Proliferation Regulation of gene expression Mice Knockout Estradiol Cell growth Estrogen Receptor alpha Endothelial Cells Estrogens Cell biology Endothelial stem cell 030104 developmental biology medicine.anatomical_structure Estrogen Female Estrogen receptor alpha |
| Zdroj: | Molecular and cellular endocrinology. 442 |
| ISSN: | 1872-8057 |
| Popis: | The unliganded form of the estrogen receptor is generally thought to be inactive. Our prior studies, however, suggested that unliganded estrogen receptor alpha (ERα) exacerbates adverse vascular injury responses in mice. Here, we show that the presence of unliganded ERα decreases vascular endothelial cell (EC) migration and proliferation, increases smooth muscle cell (SMC) proliferation, and increases inflammatory responses in cultured ECs and SMCs. Unliganded ERα also regulates many genes in vascular ECs and mouse aorta. Activation of ERα by E2 reverses the cell physiological effects of unliganded ERα, and promotes gene regulatory effects that are predicted to counter the effects of unliganded ERα. These results reveal that the unliganded form of ERα is not inert, but significantly impacts gene expression and physiology of vascular cells. Furthermore, they indicate that the cardiovascular protective effects of estrogen may be connected to its ability to counteract these effects of unliganded ERα. |
| Databáze: | OpenAIRE |
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