The Role of T Cells in Herpes Stromal Keratitis
Autor: | Barry T. Rouse, Naveen K. Rajasagi |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
CD4-Positive T-Lymphocytes
0301 basic medicine lcsh:Immunologic diseases. Allergy Immunology CD4 T cells Review CD8-Positive T-Lymphocytes T-Lymphocytes Regulatory Virus regulatory T cells Proinflammatory cytokine Lesion 03 medical and health sciences 0302 clinical medicine Immune system Amphiregulin Animals Humans Simplexvirus Immunology and Allergy Medicine Cytotoxic T cell business.industry herpes stromal keratitis Th1 Cells 030104 developmental biology plasticity Keratitis Herpetic Th17 Cells medicine.symptom business lcsh:RC581-607 metabolism CD8 Function (biology) 030215 immunology |
Zdroj: | Frontiers in Immunology, Vol 10 (2019) Frontiers in Immunology |
ISSN: | 1664-3224 |
Popis: | The blinding inflammatory lesion stromal keratitis (SK), which occurs in some patients in response to ocular herpes simplex virus (HSV) infection, represents mainly an immune cell mediated inflammatory response to the virus infection. The principal orchestrators of the immunopathological lesions are T cells although additional events participate that include the extent of recruitment of non-lymphoid cells, the extent of neoangiogenesis, and the extent of damage to nerve function. This review focuses on evidence that the balance of the functional subsets of T cells has a major impact on lesion severity and duration. Accordingly, if proinflammatory Th1 and Th17 CD4 T cells, and perhaps in some cases CD8 T cells, predominate lesions occur earlier and are more severe. Lesions are diminished when cells with regulatory function predominate. Moreover, when regulatory cells acquire the property to produce Amphiregulin this may facilitate lesion resolution. An objective to controlling lesions is to learn how to manipulate the balance of T cells to favor the representation and function of regulatory T cells and their products over proinflammatory cells. In this review we emphasize how exploiting the differential metabolic requirements of immune cells could be a valuable approach to control SK. |
Databáze: | OpenAIRE |
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