The Biomarker Potential of miRNAs in Myotonic Dystrophy Type I
| Autor: | Gisela Nogales-Gadea, Emma Koehorst, Alicia Martínez-Piñeiro, Alfonsina Ballester-Lopez, Virginia Arechavala-Gomeza |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
congenital hereditary and neonatal diseases and abnormalities lcsh:Medicine Review Bioinformatics Myotonic dystrophy 03 medical and health sciences 0302 clinical medicine Cataracts microRNA medicine therapeutics 030304 developmental biology Regulation of gene expression 0303 health sciences business.industry lcsh:R Muscle weakness biomarkers General Medicine medicine.disease Myotonia miRNAs Biomarker (medicine) Age of onset medicine.symptom business myotonic dystrophies 030217 neurology & neurosurgery |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 9, Iss 3939, p 3939 (2020) |
| ISSN: | 2077-0383 |
| Popis: | MicroRNAs (miRNAs) are mostly known for their gene regulation properties, but they also play an important role in intercellular signaling. This means that they can be found in bodily fluids, giving them excellent biomarker potential. Myotonic Dystrophy type I (DM1) is the most frequent autosomal dominant muscle dystrophy in adults, with an estimated prevalence of 1:8000. DM1 symptoms include muscle weakness, myotonia, respiratory failure, cardiac conduction defects, cataracts, and endocrine disturbances. Patients display heterogeneity in both age of onset and disease manifestation. No treatment or cure currently exists for DM1, which shows the necessity for a biomarker that can predict disease progression, providing the opportunity to implement preventative measures before symptoms arise. In the past two decades, extensive research has been conducted in the miRNA expression profiles of DM1 patients and their biomarker potential. Here we review the current state of the field with a tissue-specific focus, given the multi-systemic nature of DM1 and the intracellular signaling role of miRNAs. |
| Databáze: | OpenAIRE |
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