The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes
| Autor: | J. Schröder, Kimmo Virtaneva, Heli Nevanlinna, Baumruker T, Pavla Angelisova, Horejsí |
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| Rok vydání: | 1993 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte CD53 Tetraspanins Immunology Tetraspanin 25 CD37 Biology Kangai-1 Protein 03 medical and health sciences 0302 clinical medicine Gene mapping Antigen Antigens CD Antigens Neoplasm Proto-Oncogene Proteins Genetics Extracellular Humans Gene Glycoproteins 030304 developmental biology 0303 health sciences Membrane Glycoproteins Chromosomes Human Pair 11 Chromosome Mapping Chromosome T lymphocyte Antigens Differentiation Molecular biology Chromosomes Human Pair 1 Multigene Family Chromosomes Human Pair 19 030217 neurology & neurosurgery |
| Zdroj: | Immunogenetics. 37:461-465 |
| ISSN: | 1432-1211 0093-7711 |
| Popis: | CD37, CD53, and R2 leukocyte surface antigens are members of a novel family of structurally related proteins. They all have four transmembrane-spanning domains with a single major extracellular loop. The CD37 is expressed on B cells and on a sub-population of T cells. The CD53 is known as a panleukocyte marker. The R2 protein is an activation antigen of T cells. The CD37, CD53, and R2 genes were assigned with the help of human/rodent somatic cell hybrids and human-specific probes to human chromosomes 19, 1, and 11, respectively. For the regional assignment, various deletion hybrids were used to map CD37 to 19p13-q13.4, CD53 to 1p12-p31, and R2 to 11p12. |
| Databáze: | OpenAIRE |
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