Glutathione S-transferase polymorphisms and risk of colorectal adenomas
| Autor: | Hitomi Hayabuchi, Emiko Tsuji, Sachiko Shinomiya, Tomomi Marugame, Hisako Inoue, Hiroyuki Eguchi, Yoshitaka Fukushima, Koichi Handa, Suminori Kono, Chikako Kiyohara |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adenoma
Male Risk Cancer Research medicine.medical_specialty Genotype Colorectal cancer Rectum Detoxification enzymes medicine.disease_cause Gastroenterology Cigarette smoking Internal medicine medicine Biomarkers Tumor Odds Ratio Humans neoplasms Glutathione Transferase integumentary system biology business.industry Smoking Middle Aged medicine.disease Neoplasm Proteins Glutathione S-transferase medicine.anatomical_structure Endocrinology Oncology biology.protein Regression Analysis business Carcinogenesis Colorectal Neoplasms |
| Zdroj: | Cancer letters. 163(2) |
| ISSN: | 0304-3835 |
| Popis: | Glutathione S-transferases (GSTs) are a superfamily of detoxification enzymes that may play an important role in human carcinogenesis. While the genetic polymorphisms GSTM1 and GSTT1 have drawn particular interest in relation to cancer susceptibility, previous studies of colorectal cancer are inconsistent regarding their role. We examined the relation between GSTM1 and GSTT1 genotypes combined and colorectal adenomas, and the interaction with cigarette smoking among 205 cases of colorectal adenomas and 220 controls with normal total colonoscopy in Japanese men. Neither GSTM1 nor GSTT1 was related to colorectal adenomas, nor were the null genotypes of GSTM1 and GSTT1 combined. The lack of an association with GSTM1 and GSTT1 genotypes combined persisted even when the analysis was done separately for proximal and distal colorectal adenomas. A three- to fivefold significant increase in the odds of colorectal adenomas was observed among men with a high exposure to cigarette smoking across the genotype groups, and a statistically significant increasing trend was noted within each genotype group. The present findings do not support the role for GSTM1 and GSTT1 genotypes in the development of colorectal adenomas. |
| Databáze: | OpenAIRE |
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