Antihyperglycemic Effect of Andrographolide in Streptozotocin-Induced Diabetic Rats

Autor: Wang-Chuan Chen, Juei-Tang Cheng, Chen-Road Hung, Bu-Chin Yu
Rok vydání: 2003
Předmět:
Blood Glucose
Male
endocrine system diseases
Andrographolide
medicine.medical_treatment
Administration
Oral
Muscle Proteins
Pharmaceutical Science
Analytical Chemistry
chemistry.chemical_compound
Drug Discovery
Glucose Transporter Type 4
biology
Molecular Medicine
Diterpenes
Andrographis paniculata
medicine.drug
medicine.medical_specialty
Monosaccharide Transport Proteins
Carbohydrate metabolism
Streptozocin
Diabetes Mellitus
Experimental
Diabetes mellitus
Internal medicine
medicine
Animals
Hypoglycemic Agents
RNA
Messenger
Rats
Wistar
Muscle
Skeletal
Pharmacology
Dose-Response Relationship
Drug
business.industry
Insulin
Organic Chemistry
Glucose transporter
medicine.disease
Streptozotocin
biology.organism_classification
Rats
Plant Leaves
Glucose
Endocrinology
Complementary and alternative medicine
chemistry
biology.protein
Andrographis
business
GLUT4
Phytotherapy
Zdroj: Planta Medica. 69:1075-1079
ISSN: 1439-0221
0032-0943
DOI: 10.1055/s-2003-45185
Popis: The antihyperglycemic action of andrographolide, an active principle in the leaves of Andrographis paniculata (Burm. f.) Nees, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats). Oral treatment of andrographolide decreased the plasma glucose concentrations of STZ-diabetic rats in a dose-dependent manner. Similar treatment with andrographolide also decreased the plasma glucose in normal rats and the maximal effect was more marked than that in STZ-diabetic rats. Andrographolide at the effective dose (1.5 mg/kg) significantly attenuated the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. In the isolated soleus muscle of STZ-diabetic rats, andrographolide enhanced the uptake of radioactive glucose in a concentration-dependent manner. Moreover, the mRNA and protein levels of the subtype 4 form of the glucose transporter (GLUT4) in soleus muscle were increased after repeated intravenous administration of andrographolide in STZ-diabetic rats for 3 days. These results suggest that andrographolide can increase the glucose utilization to lower plasma glucose in diabetic rats lacking insulin.
Databáze: OpenAIRE
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