Spontaneous Muscle Hematoma in Japanese Patients with Severe COVID-19 Treated with Unfractionated Heparin: Two Case Reports
| Autor: | Ryuta Yamashita, Fumiya Uchiyama, Nobuyasu Awano, Minoru Inomata, Kazushi Fujimoto, Jun-ichi Nishimura, Yutaka Muto, Mari Tone, Akinori Harada, Naoyuki Kuse, Munehiro Hayashi, Takehiro Izumo, Yu Ito, Kenro Maki, Kohei Takada, Shogo Sagisaka |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19) Iliopsoas Muscle Transcatheter embolization MUSCLE HEMATOMA Case Report therapeutic anticoagulation Computed tomography Partial prothrombin time spontaneous muscle hematoma Japan Internal Medicine medicine Humans Hematoma medicine.diagnostic_test Heparin SARS-CoV-2 business.industry Muscles Anticoagulants COVID-19 General Medicine vascular dysfunction unfractionated heparin medicine.disease Thrombosis Surgery business medicine.drug |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.7422-21 |
| Popis: | In hospitalized coronavirus disease 2019 (COVID-19) patients, anticoagulation therapy is administered to prevent thrombosis. However, anticoagulation sometimes causes bleeding complications. We herein report two Japanese cases of severe COVID-19 in which spontaneous muscle hematomas (SMH) developed under therapeutic anticoagulation with unfractionated heparin. Although the activated partial prothrombin time was within the optimal range, contrast-enhanced computed tomography (CECT) revealed SMH in the bilateral iliopsoas muscles in both cases, which required emergent transcatheter embolization. Close monitoring of the coagulation system and the early diagnosis of bleeding complications through CECT are needed in severe COVID-19 patients treated with anticoagulants. |
| Databáze: | OpenAIRE |
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