How a cyanobacterium tells time
| Autor: | Guogang Dong, Susan S. Golden |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Synechococcus
Microbiology (medical) Light biology Circadian Rhythm Signaling Peptides and Proteins Circadian clock Gene Expression Regulation Bacterial macromolecular substances Darkness biology.organism_classification Microbiology Article Bacterial circadian rhythms Circadian Rhythm Cell biology Infectious Diseases Bacterial Proteins Transcription (biology) KaiC KaiA Phosphorylation Signal transduction |
| Zdroj: | Current Opinion in Microbiology. 11:541-546 |
| ISSN: | 1369-5274 |
| Popis: | The cyanobacterium Synechococcus elongatus builds a circadian clock on an oscillator comprised of three proteins, KaiA, KaiB, and KaiC, which can recapitulate a circadian rhythm of KaiC phosphorylation in vitro. The molecular structures of all three proteins are known, and the phosphorylation steps of KaiC, the interaction dynamics among the three Kai proteins, and a weak ATPase activity of KaiC have all been characterized. An input pathway of redox-sensitive proteins uses photosynthetic function to relay light/dark information to the oscillator, and signal transduction proteins of well-known families broadcast temporal information to the genome, where global changes in transcription and a compaction of the chromosome are clock regulated. |
| Databáze: | OpenAIRE |
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