Evaluation of an oral bile acid loading test for assessment of liver function in chronic hepatitis A comparison with fasting serum bile acids and i.v. galactose elimination test
| Autor: | P Tobiasson, B Kågedal, U. Foberg, C. Broström, Hans Glaumann, Aril Frydén, Ola Weiland, J. Mårtensson |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Cirrhosis medicine.drug_class Cholic Acid Chenodeoxycholic Acid Hepatitis chemistry.chemical_compound Liver disease Liver Function Tests Chenodeoxycholic acid Internal medicine medicine Humans Aged Hepatitis Chronic Hepatology medicine.diagnostic_test Bile acid business.industry Cholic acid Galactose Cholic Acids Middle Aged medicine.disease Endocrinology Liver chemistry Female Liver function Liver function tests business |
| Zdroj: | Liver. 7:116-122 |
| ISSN: | 0106-9543 |
| DOI: | 10.1111/j.1600-0676.1987.tb00327.x |
| Popis: | In 40 patients with histologically verified chronic hepatitis, (chronic persistent hepatitis, n = 13; chronic active hepatitis without, n = 14; or with cirrhosis, n = 13), of viral and autoimmune origin, serum bile acids (SBA) were measured before and during 3 h after oral ingestion of 1 g chenodeoxycholic acid (CDA). Fasting SBA were elevated in 22 (55%) patients, whereas the CDA loading test was abnormal in 15 (38%) patients and the galactose elimination was prolonged in 16 (40%) patients. In patients with chronic active hepatitis, 20/27 had elevated SBA either in the fasting state (18/27) or after the CDA loading test (13/27). Normal SBA values were found in 9/13 (70%) patients with chronic persistent hepatitis. Thus, fasting SBA is not sensitive enough to detect mild chronic inflammatory liver disease as chronic persistent hepatitis, but seems to be as sensitive as the galactose elimination or CDA loading tests in detecting potential severe liver disease. Fasting SBA may thus be used as a complement of conventional liver tests in the follow-up of chronic hepatitis as assessment of liver function. An oral CDA loading and an i.v. galactose elimination test add no further information to that given by fasting serum bile acids. |
| Databáze: | OpenAIRE |
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