Malignant (Diffuse) Mesothelioma in Patients With Hematologic Malignancies: A Clinicopathologic Study of 45 Cases
| Autor: | Xin Li, Thomas A. Sporn, Victor L. Roggli, Annabelle Mahar, Noel A. Brownlee |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Adult Male Mesothelioma medicine.medical_specialty Lung Neoplasms Neoplasms Radiation-Induced Time Factors Adolescent medicine.medical_treatment Chronic lymphocytic leukemia Kaplan-Meier Estimate Malignancy Pathology and Forensic Medicine Neoplasms Multiple Primary Myelogenous Young Adult Risk Factors Internal medicine Leukemia Myelogenous Chronic BCR-ABL Positive medicine Humans Child Aged Aged 80 and over Radiotherapy business.industry Lymphoma Non-Hodgkin Mesothelioma Malignant Asbestos General Medicine Middle Aged medicine.disease Hodgkin Disease Leukemia Lymphocytic Chronic B-Cell Lymphoma Radiation therapy Medical Laboratory Technology Leukemia Hematologic Neoplasms Female business Chronic myelogenous leukemia |
| Zdroj: | Archives of pathologylaboratory medicine. 139(9) |
| ISSN: | 1543-2165 |
| Popis: | ContextIonizing radiation has a role in the development of malignant mesothelioma, in several epidemiologic studies, including patients with hematologic malignancies.ObjectiveTo study the clinicopathologic characteristics of patients with malignant mesothelioma and hematologic malignancies with and without a history of radiotherapy.DesignFrom a database of approximately 3600 patients with malignant mesothelioma, we identified 45 patients (1%) who also had hematologic malignancies. We examined clinicopathologic features and noted whether the patient had received radiotherapy for malignancy, comparing those with and those without such exposure.ResultsAmong the 45 cases, 18 (40%) had Hodgkin lymphoma, 15 (33%) had non-Hodgkin lymphoma, 10 (4%) had chronic lymphocytic leukemia, and 2 (22%) had chronic myelogenous leukemia; 20 patients (44%) had a history of radiotherapy, and 23 (51%) did not. Most patients with Hodgkin lymphoma (16 of 18; 90.0%) received radiation, whereas none of the patients with leukemia (0 of 12) and only 20% (3 of 15) of the patients with non-Hodgkin lymphoma did so. Patients without radiation were older than patients who received radiotherapy (median, 73 versus 54 years, respectively; P < .001), had a shorter interval from diagnosis of hematologic malignancy to that of mesothelioma (median, 2 versus 24 years, respectively; P < .001), and had a shorter survival period (median, 6.0 versus 14.0 months, respectively; P = .02). Epithelial mesotheliomas were proportionately more common in patients with a history of radiotherapy.ConclusionsPatients with mesothelioma and hematologic malignancies with a history of radiation tended to be younger, had a longer interval from diagnosis of hematologic malignancy to that of mesothelioma, had a longer survival period, and were more likely to have the epithelial variant compared with patients without radiotherapy. |
| Databáze: | OpenAIRE |
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