Pharmacokinetics of cefepime in bile and gall bladder tissue after prophylactic administration in patients with extrahepatic biliary diseases
| Autor: | Elias Bastounis, Nicholaos Katsilambros, Seraphim Kastanakis, Papachristodoulou Antonios, Antonios Markogiannakis, George Petrikkos, Miltiadis Kastanakis, George L. Daikos |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Microbiology (medical) Pathology medicine.medical_specialty Adolescent medicine.drug_class medicine.medical_treatment Cefepime Antibiotics Gallbladder Diseases Gastroenterology Polyps Internal medicine Cholecystitis Bile Humans Medicine Cholecystectomy Pharmacology (medical) Antibiotic prophylaxis Aged Antibacterial agent business.industry Gallbladder Cholecystolithiasis General Medicine Antibiotic Prophylaxis Middle Aged Anti-Bacterial Agents Cephalosporins Infectious Diseases medicine.anatomical_structure Biliary tract Area Under Curve Female Biliary Tract Surgery business medicine.drug |
| Zdroj: | International Journal of Antimicrobial Agents. 27:331-334 |
| ISSN: | 0924-8579 |
| DOI: | 10.1016/j.ijantimicag.2005.11.007 |
| Popis: | The purpose of this study was to determine the cefepime concentrations in serum, bile and gall bladder tissue after administration of a single dose in patients with extrahepatic biliary diseases for pre-operative antimicrobial prophylaxis. During a 3-year period (1999-2002), 30 patients aged above 18 years with extrahepatic biliary diseases (acute and chronic cholecystitis and symptomatic cholelithiasis) were included in the study. Cefepime concentrations were determined by the agar microbiological diffusion method. A significant correlation between serum and gall bladder tissue concentrations of cefepime with the sampling interval was observed (r2 = 0.771, P |
| Databáze: | OpenAIRE |
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