Role of 5-HT3 and 5-HT2C receptors located within the medial amygdala in the control of salt intake in sodium-depleted rats
| Autor: | Emilio de Castro e Silva, C.P. Luz, Rodolfo Reis, Anderson Santos Souza, Josmara Bartolomei Fregoneze |
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| Rok vydání: | 2005 |
| Předmět: |
Agonist
Male medicine.medical_specialty Time Factors medicine.drug_class Biguanides Drinking SDZ SER-082 5-HT3 receptor chemistry.chemical_compound Saccharin Furosemide Internal medicine medicine Avoidance Learning Receptor Serotonin 5-HT2C Animals Drug Interactions Renal Insufficiency Salt intake Rats Wistar Receptor Molecular Biology 5-HT receptor Analysis of Variance biology Behavior Animal Dose-Response Relationship Drug General Neuroscience Sodium Feeding Behavior Receptor antagonist Amygdala Ondansetron Rats Serotonin Receptor Agonists 5-HT2C receptor Endocrinology chemistry biology.protein Neurology (clinical) Serotonin Antagonists Receptors Serotonin 5-HT3 Developmental Biology |
| Zdroj: | Brain research. 1099(1) |
| ISSN: | 0006-8993 |
| Popis: | In the present study, we investigated the role of 5-HT(3) and 5-HT(2C) receptors located within the medial amygdala (MeA) in the control of water and salt intake in sodium-depleted rats. Pharmacological activation of 5-HT(3) receptors located in the medial amygdala by the selective 5-HT(3) receptor agonist m-CPBG significantly reduced salt intake in sodium-depleted rats, an effect that is reverted by pretreatment with the selective 5-HT(3) receptor antagonist ondansetron. In addition, the injection of ondansetron alone into the medial amygdala had no effect on salt intake in sodium-depleted and in sodium-repleted rats. Pharmacological stimulation of 5-HT(2C) receptors located in the medial amygdala by the selective 5-HT(2C) receptor agonist m-CPP failed to modify salt intake in sodium-depleted rats, whereas the blockade of these receptors by the selective 5-HT(2C) receptor antagonist SDZ SER 082 significantly reduced salt intake in this same group of animals. These results lead to the conclusion that the pharmacological activation of 5-HT(3) receptors located within the MeA inhibits salt intake in sodium-depleted rats and that, in this same brain region, the functional integrity of 5-HT(2C) receptors is required to achieve the full expression of sodium appetite in sodium-depleted rats. |
| Databáze: | OpenAIRE |
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